The epidermal pentapeptide pyroglu-Glu-Asp-Ser-GlyOH inhibits murine hair growth in vivo and in vitro

Ralf Paus, K. S. Stenn, K. Elgjo

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Tissue growth may be controlled by negative feedback mechanisms. Recently, a pentapeptide, pyroGlu-Glu-Asp-Ser-GlyOH ('epidermal pentapeptide', EPP), which slows the growth of mouse epidermis in vivo and of mouse keratinocytes in vitro, was isolated from mouse epidermis. Since inhibitory molecules like EPP might be part of the feedback systems underlying hair growth control, we assessed the effect of synthesized EPP on the growth of hair follicles, using rodent in vivo and in vitro assays. We report for the first time that intraperitoneally injected EPP (30 nmol/animal/day over 6 days) significantly slows the growth of hair follicles in plucking-induced anagen skin of C57B1-6 mice (as assessed by microscopic morphometry). Using an in vitro organ culture assay, EPP inhibits the incorporation of 3H-thymidine into mouse pelage anagen follicles. That this epidermal-derived peptide affects hair growth raises the possibility that hair growth may be regulated by an inhibition/disinhibition mechanism under participation of EPP-like molecules and that the epidermis may play a role in the control of hair growth.

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
JournalDermatologica
Volume183
Issue number3
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Hair
Growth
Epidermis
Hair Follicle
epidermal pentapeptide
In Vitro Techniques
Organ Culture Techniques
Keratinocytes
Thymidine
Rodentia
Skin
Peptides

Keywords

  • anagen inhibition
  • epidermal pentapeptide
  • hair growth

ASJC Scopus subject areas

  • Dermatology

Cite this

The epidermal pentapeptide pyroglu-Glu-Asp-Ser-GlyOH inhibits murine hair growth in vivo and in vitro. / Paus, Ralf; Stenn, K. S.; Elgjo, K.

In: Dermatologica, Vol. 183, No. 3, 01.01.1991, p. 173-178.

Research output: Contribution to journalArticle

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