The epidemiology of high-risk prostate cancer

Sanoj Punnen, Matthew R. Cooperberg

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


PURPOSE OF REVIEW: Concern for over and under-treatment of men with prostate cancer has led to an increased focus on the identification and selective treatment of men with high-risk features. The purpose of this review is to summarize the epidemiology, risk factors, and treatment trends of men with high-risk prostate cancer. RECENT FINDINGS: Findings from recent trials on prostate-specific antigen-based screening suggest that screening has substantially reduced the incidence of high-risk prostate cancer. Men with high-risk disease tend to be older at diagnosis than those with low-risk disease. There is marked variation in the treatment of men with high-risk features; contemporary studies favor multimodal therapy, but high-risk disease is often under-treated with androgen deprivation alone, particularly among older men. SUMMARY: Variations in the incidence, mortality, and treatment of men with high-risk prostate cancer may reflect heterogeneity among studies in the definition of high-risk disease. Future research should attempt to standardize definitions of high-risk prostate cancer to allow better comparison between studies and provide a more homogeneous assessment of natural history.

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalCurrent opinion in urology
Issue number4
StatePublished - Jul 2013
Externally publishedYes


  • epidemiology
  • high risk
  • prostate cancer
  • prostate neoplasms
  • risk assessment

ASJC Scopus subject areas

  • Urology


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