The endothelium as the common denominator in malignant hypertension and thrombotic microangiopathy

Roy O. Mathew, Ali Nayer, Arif Asif

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The endothelium plays a pivotal role in vascular biology. The endothelium is the primary site of injury in thrombotic microangiopathies including malignant hypertension. Endothelial injury in thrombotic microangiopathies is the result of increased shear stress, toxins, and/or dysregulated complement activation. Endothelial injury can lead to microvascular thrombosis resulting in ischemia and organ dysfunction, the clinical hallmarks of thrombotic microangiopathies. Currently, available therapies target the underlying mechanisms that lead to endothelial injury in these conditions. Ongoing investigations aim at identifying drugs that protect the endothelium.

Original languageEnglish (US)
JournalJournal of the American Society of Hypertension
DOIs
StateAccepted/In press - Sep 8 2015

Keywords

  • Endothelial dysfunction
  • Hemolytic uremic syndrome
  • Malignant hypertension
  • Thrombotic microangiopathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

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