The endothelium as the common denominator in malignant hypertension and thrombotic microangiopathy

Roy O. Mathew, Ali Nayer, Arif Asif

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The endothelium plays a pivotal role in vascular biology. The endothelium is the primary site of injury in thrombotic microangiopathies including malignant hypertension. Endothelial injury in thrombotic microangiopathies is the result of increased shear stress, toxins, and/or dysregulated complement activation. Endothelial injury can lead to microvascular thrombosis resulting in ischemia and organ dysfunction, the clinical hallmarks of thrombotic microangiopathies. Currently, available therapies target the underlying mechanisms that lead to endothelial injury in these conditions. Ongoing investigations aim at identifying drugs that protect the endothelium.

Original languageEnglish (US)
JournalJournal of the American Society of Hypertension
DOIs
StateAccepted/In press - Sep 8 2015

Fingerprint

Thrombotic Microangiopathies
Malignant Hypertension
Endothelium
Wounds and Injuries
Complement Activation
Blood Vessels
Thrombosis
Ischemia
Pharmaceutical Preparations

Keywords

  • Endothelial dysfunction
  • Hemolytic uremic syndrome
  • Malignant hypertension
  • Thrombotic microangiopathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

The endothelium as the common denominator in malignant hypertension and thrombotic microangiopathy. / Mathew, Roy O.; Nayer, Ali; Asif, Arif.

In: Journal of the American Society of Hypertension, 08.09.2015.

Research output: Contribution to journalArticle

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