TY - JOUR
T1 - The endocannabinoid system of the skin in health and disease
T2 - novel perspectives and therapeutic opportunities
AU - Bíró, Tamás
AU - Tóth, Balázs I.
AU - Haskó, György
AU - Paus, Ralf
AU - Pacher, Pál
N1 - Funding Information:
This publication was supported by Intramural Research Program of the National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism ( www.nih.gov ; www.niaaa.nih.gov ; to P.P.) and by the Hungarian Scientific Research Fund ( www.otka.hu ; OTKA 63153 to T.B.).
PY - 2009/8
Y1 - 2009/8
N2 - The newly discovered endocannabinoid system (ECS; comprising the endogenous lipid mediators endocannabinoids present in virtually all tissues, their G-protein-coupled cannabinoid receptors, biosynthetic pathways and metabolizing enzymes) has been implicated in multiple regulatory functions both in health and disease. Recent studies have intriguingly suggested the existence of a functional ECS in the skin and implicated it in various biological processes (e.g. proliferation, growth, differentiation, apoptosis and cytokine, mediator or hormone production of various cell types of the skin and appendages, such as the hair follicle and sebaceous gland). It seems that the main physiological function of the cutaneous ECS is to constitutively control the proper and well-balanced proliferation, differentiation and survival, as well as immune competence and/or tolerance, of skin cells. The disruption of this delicate balance might facilitate the development of multiple pathological conditions and diseases of the skin (e.g. acne, seborrhea, allergic dermatitis, itch and pain, psoriasis, hair growth disorders, systemic sclerosis and cancer).
AB - The newly discovered endocannabinoid system (ECS; comprising the endogenous lipid mediators endocannabinoids present in virtually all tissues, their G-protein-coupled cannabinoid receptors, biosynthetic pathways and metabolizing enzymes) has been implicated in multiple regulatory functions both in health and disease. Recent studies have intriguingly suggested the existence of a functional ECS in the skin and implicated it in various biological processes (e.g. proliferation, growth, differentiation, apoptosis and cytokine, mediator or hormone production of various cell types of the skin and appendages, such as the hair follicle and sebaceous gland). It seems that the main physiological function of the cutaneous ECS is to constitutively control the proper and well-balanced proliferation, differentiation and survival, as well as immune competence and/or tolerance, of skin cells. The disruption of this delicate balance might facilitate the development of multiple pathological conditions and diseases of the skin (e.g. acne, seborrhea, allergic dermatitis, itch and pain, psoriasis, hair growth disorders, systemic sclerosis and cancer).
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U2 - 10.1016/j.tips.2009.05.004
DO - 10.1016/j.tips.2009.05.004
M3 - Review article
C2 - 19608284
AN - SCOPUS:67849092895
VL - 30
SP - 411
EP - 420
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
SN - 0165-6147
IS - 8
ER -