The emerging role of deubiquitination in nucleotide excision repair

Ling Zhang, Feng Gong

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Nucleotide excision repair (NER) protects genome stability by eliminating DNA helix distorting lesions, such as those induced by UV radiation. The addition and removal of ubiquitin, namely, ubiquitination and deubiquitination, have recently been demonstrated as general mechanisms to regulate protein functions. Accumulating evidence shows that several NER factors are subjected to extensive regulation by ubiquitination and deubiquitination. Thus, the balance between E3 ligases and deubiquitinating enzyme activities can dynamically alter the ubiquitin landscape at DNA damage sites, thereby regulating NER efficiency. Current knowledge about XPC ubiquitination by different ubiquitin E3 ligases highlights the importance of ubiquitin linkage types in regulating XPC binding and release from damaged DNA. Here, we discuss the emerging roles of deubiquitinating enzymes and their ubiquitin linkage specificities in NER.

Original languageEnglish (US)
JournalDNA Repair
DOIs
StateAccepted/In press - 2016

Fingerprint

Ubiquitin
DNA Repair
Ubiquitination
Repair
Nucleotides
Ubiquitin-Protein Ligases
DNA
Genomic Instability
Enzyme activity
Ultraviolet radiation
DNA Damage
Genes
Radiation
Enzymes
Proteins
Deubiquitinating Enzymes

Keywords

  • Deubiquitination
  • DUBs
  • E3 ubiquitin ligase
  • GG-NER
  • Segregase
  • TC-NER
  • Ubiquitin linkage specificity
  • Ubiquitination

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

The emerging role of deubiquitination in nucleotide excision repair. / Zhang, Ling; Gong, Feng.

In: DNA Repair, 2016.

Research output: Contribution to journalArticle

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