Abstract
P-glycoprotein, breast cancer resistance protein, and multidrug resistance proteins have physiological functions in placental tissue. Several antidepressants, antipsychotics, and anti-epileptic drugs have been found to be substrates of P-glycoprotein and other transporters. The extent that drugs pass through the placental barrier is likely influenced by drug transporters. The rational choice of psychoactive drugs to treat mental illness in women of child-bearing age should incorporate knowledge of both drug disposition as well as expected pharmacologic effects. This review summarizes the current data on drug transporters in the placental passage of medications, with a focus on medications used in clinical psychopharmacology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 723-746 |
| Number of pages | 24 |
| Journal | Drug Metabolism Reviews |
| Volume | 39 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2007 |
| Externally published | Yes |
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Keywords
- Breast cancer resistance protein
- Drug transporters
- Multi-drug resistance protein
- P-glycoprotein
- Pregnancy
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology
Cite this
The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patient. / Wang, Jun Sheng; Newport, Donald J; Stowe, Zachary N.; Donovan, Jennifer L.; Pennell, Page B.; DeVane, C. Lindsay.
In: Drug Metabolism Reviews, Vol. 39, No. 4, 10.2007, p. 723-746.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patient
AU - Wang, Jun Sheng
AU - Newport, Donald J
AU - Stowe, Zachary N.
AU - Donovan, Jennifer L.
AU - Pennell, Page B.
AU - DeVane, C. Lindsay
PY - 2007/10
Y1 - 2007/10
N2 - P-glycoprotein, breast cancer resistance protein, and multidrug resistance proteins have physiological functions in placental tissue. Several antidepressants, antipsychotics, and anti-epileptic drugs have been found to be substrates of P-glycoprotein and other transporters. The extent that drugs pass through the placental barrier is likely influenced by drug transporters. The rational choice of psychoactive drugs to treat mental illness in women of child-bearing age should incorporate knowledge of both drug disposition as well as expected pharmacologic effects. This review summarizes the current data on drug transporters in the placental passage of medications, with a focus on medications used in clinical psychopharmacology.
AB - P-glycoprotein, breast cancer resistance protein, and multidrug resistance proteins have physiological functions in placental tissue. Several antidepressants, antipsychotics, and anti-epileptic drugs have been found to be substrates of P-glycoprotein and other transporters. The extent that drugs pass through the placental barrier is likely influenced by drug transporters. The rational choice of psychoactive drugs to treat mental illness in women of child-bearing age should incorporate knowledge of both drug disposition as well as expected pharmacologic effects. This review summarizes the current data on drug transporters in the placental passage of medications, with a focus on medications used in clinical psychopharmacology.
KW - Breast cancer resistance protein
KW - Drug transporters
KW - Multi-drug resistance protein
KW - P-glycoprotein
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=36749058980&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36749058980&partnerID=8YFLogxK
U2 - 10.1080/03602530701690390
DO - 10.1080/03602530701690390
M3 - Article
C2 - 18058331
AN - SCOPUS:36749058980
VL - 39
SP - 723
EP - 746
JO - Drug Metabolism Reviews
JF - Drug Metabolism Reviews
SN - 0360-2532
IS - 4
ER -