The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patient

Jun Sheng Wang, D. Jeffrey Newport, Zachary N. Stowe, Jennifer L. Donovan, Page B. Pennell, C. Lindsay DeVane

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

P-glycoprotein, breast cancer resistance protein, and multidrug resistance proteins have physiological functions in placental tissue. Several antidepressants, antipsychotics, and anti-epileptic drugs have been found to be substrates of P-glycoprotein and other transporters. The extent that drugs pass through the placental barrier is likely influenced by drug transporters. The rational choice of psychoactive drugs to treat mental illness in women of child-bearing age should incorporate knowledge of both drug disposition as well as expected pharmacologic effects. This review summarizes the current data on drug transporters in the placental passage of medications, with a focus on medications used in clinical psychopharmacology.

Original languageEnglish (US)
Pages (from-to)723-746
Number of pages24
JournalDrug Metabolism Reviews
Volume39
Issue number4
DOIs
StatePublished - Oct 1 2007

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Keywords

  • Breast cancer resistance protein
  • Drug transporters
  • Multi-drug resistance protein
  • P-glycoprotein
  • Pregnancy

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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