The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patient

Jun Sheng Wang; D. Jeffrey Newport; Zachary N. Stowe; Jennifer L. Donovan; Page B. Pennell; C. Lindsay DeVane

doi:10.1080/03602530701690390

The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patient

Jun Sheng Wang, D. Jeffrey Newport, Zachary N. Stowe, Jennifer L. Donovan, Page B. Pennell, C. Lindsay DeVane

Research output: Contribution to journal › Review article

23 Scopus citations

Abstract

P-glycoprotein, breast cancer resistance protein, and multidrug resistance proteins have physiological functions in placental tissue. Several antidepressants, antipsychotics, and anti-epileptic drugs have been found to be substrates of P-glycoprotein and other transporters. The extent that drugs pass through the placental barrier is likely influenced by drug transporters. The rational choice of psychoactive drugs to treat mental illness in women of child-bearing age should incorporate knowledge of both drug disposition as well as expected pharmacologic effects. This review summarizes the current data on drug transporters in the placental passage of medications, with a focus on medications used in clinical psychopharmacology.

Original language	English (US)
Pages (from-to)	723-746
Number of pages	24
Journal	Drug Metabolism Reviews
Volume	39
Issue number	4
DOIs	https://doi.org/10.1080/03602530701690390
State	Published - Oct 1 2007
Externally published	Yes

Keywords

Breast cancer resistance protein
Drug transporters
Multi-drug resistance protein
P-glycoprotein
Pregnancy

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology (medical)

Access to Document

10.1080/03602530701690390

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Cite this

Wang, J. S., Newport, D. J., Stowe, Z. N., Donovan, J. L., Pennell, P. B., & DeVane, C. L. (2007). The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patient. Drug Metabolism Reviews, 39(4), 723-746. https://doi.org/10.1080/03602530701690390

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AU - DeVane, C. Lindsay

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