The electrophysiologic effects of propafenone hydrochloride in the neonatal canine

Juan Villafane, Henry Gelband, Hui Xu, Jorge McCormack, Adrienne Stolft, Arthur S. Pickoff

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The electrophysiologic effects of the new antiarrhythmic agent, propafenone, were investigated in 10 mongrel canine neonates, ages 5 to 11 days. Utilizing standard His bundle recording and stimulation techniques, assessments of sinus and atrioventricular (AV) node function and atrial, AV nodal, and ventricular refractory periods were performed prior to (control) and after cumulative intravenous doses of 1, 2, and 4 mg/kg of propafenone. Propafenone depressed the spontaneous heart rate and prolonged the postatrial pacing recovery times. AV nodal function was depressed as manifested by Wenckebach periodicity occurring at slower pacing rates, increases in AV nodal refractoriness. Atrial and ventricular refractory periods were prolonged significantly in a dose-dependent fashion. Prolongation of the His-Purkinje conduction time occurred at the highest dose. Thus, propafenone exerts a generalized depressant effect on neonatal myocardial conduction and refractoriness which suggests that this agent may be useful in the therapy of atrial and ventricular dysrhythmias in the immature heart.

Original languageEnglish (US)
Pages (from-to)50-54
Number of pages5
JournalPediatric Research
Volume22
Issue number1
DOIs
StatePublished - Jul 1987

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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