The electrophysiologic effects of propafenone hydrochloride in the neonatal canine

J. Villafane, H. Gelband, H. Xu, J. McCormack, A. Stolfi, A. S. Pickoff

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The electrophysiologic effects of the new antiarrhythmic agent, propafenone, were investigated in 10 mongrel canine neonates, ages 5 to 11 days. Utilizing standard His bundle recording and stimulation techniques, assessments of sinus and atrioventricular (AV) node function and atrial, AV nodal, and ventricular refractory periods were performed prior to (control) and after cumulative intravenous doses of 1, 2, and 4 mg/kg of propafenone. Propafenone depressed the spontaneous heart rate and prolonged the postatrial pacing recovery times. AV nodal function was depressed as manifested by Wenckebach periodicity occurring at slower pacing rates, increases in AV nodal refractoriness. Atrial and ventricular refractory periods were prolonged significantly in a dose-dependent fashion. Prolongation of the His-Purkinje conduction time occurred at the highest dose. Thus, propafenone exerts a generalized depressant effect on neonatal myocardial conduction and refractoriness which suggests that this agent may be useful in the therapy of atrial and ventricular dysrhythmias in the immature heart.

Original languageEnglish
Pages (from-to)50-54
Number of pages5
JournalPediatric Research
Volume22
Issue number1
StatePublished - Aug 11 1987
Externally publishedYes

Fingerprint

Propafenone
Canidae
Atrial Function
Bundle of His
Atrioventricular Node
Sinoatrial Node
Periodicity
Heart Rate

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Villafane, J., Gelband, H., Xu, H., McCormack, J., Stolfi, A., & Pickoff, A. S. (1987). The electrophysiologic effects of propafenone hydrochloride in the neonatal canine. Pediatric Research, 22(1), 50-54.

The electrophysiologic effects of propafenone hydrochloride in the neonatal canine. / Villafane, J.; Gelband, H.; Xu, H.; McCormack, J.; Stolfi, A.; Pickoff, A. S.

In: Pediatric Research, Vol. 22, No. 1, 11.08.1987, p. 50-54.

Research output: Contribution to journalArticle

Villafane, J, Gelband, H, Xu, H, McCormack, J, Stolfi, A & Pickoff, AS 1987, 'The electrophysiologic effects of propafenone hydrochloride in the neonatal canine', Pediatric Research, vol. 22, no. 1, pp. 50-54.
Villafane J, Gelband H, Xu H, McCormack J, Stolfi A, Pickoff AS. The electrophysiologic effects of propafenone hydrochloride in the neonatal canine. Pediatric Research. 1987 Aug 11;22(1):50-54.
Villafane, J. ; Gelband, H. ; Xu, H. ; McCormack, J. ; Stolfi, A. ; Pickoff, A. S. / The electrophysiologic effects of propafenone hydrochloride in the neonatal canine. In: Pediatric Research. 1987 ; Vol. 22, No. 1. pp. 50-54.
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