The efficiency of protein compartmentalization into the secretory pathway

Corinna Levine, Devarati Mitra, Ajay Sharma, Carolyn L. Smith, Ramanujan S. Hegde

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Numerous proteins targeted for the secretory pathway are increasingly implicated in functional or pathological roles at alternative cellular destinations. The parameters that allow secretory or membrane proteins to reside in intracellular locales outside the secretory pathway remain largely unexplored. In this study, we have used an extremely sensitive and quantitative assay to measure the in vivo efficiency of signal sequence-mediated protein segregation into the secretory pathway. Our findings reveal that segregation efficiency varies tremendously among signals, ranging from >95 to

Original languageEnglish (US)
Pages (from-to)279-291
Number of pages13
JournalMolecular Biology of the Cell
Volume16
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

Fingerprint

Secretory Pathway
Proteins
Protein Sorting Signals
Membrane Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

The efficiency of protein compartmentalization into the secretory pathway. / Levine, Corinna; Mitra, Devarati; Sharma, Ajay; Smith, Carolyn L.; Hegde, Ramanujan S.

In: Molecular Biology of the Cell, Vol. 16, No. 1, 01.2005, p. 279-291.

Research output: Contribution to journalArticle

Levine, Corinna ; Mitra, Devarati ; Sharma, Ajay ; Smith, Carolyn L. ; Hegde, Ramanujan S. / The efficiency of protein compartmentalization into the secretory pathway. In: Molecular Biology of the Cell. 2005 ; Vol. 16, No. 1. pp. 279-291.
@article{fb5599eaf7444fe781cc3a658f08ac22,
title = "The efficiency of protein compartmentalization into the secretory pathway",
abstract = "Numerous proteins targeted for the secretory pathway are increasingly implicated in functional or pathological roles at alternative cellular destinations. The parameters that allow secretory or membrane proteins to reside in intracellular locales outside the secretory pathway remain largely unexplored. In this study, we have used an extremely sensitive and quantitative assay to measure the in vivo efficiency of signal sequence-mediated protein segregation into the secretory pathway. Our findings reveal that segregation efficiency varies tremendously among signals, ranging from >95 to",
author = "Corinna Levine and Devarati Mitra and Ajay Sharma and Smith, {Carolyn L.} and Hegde, {Ramanujan S.}",
year = "2005",
month = "1",
doi = "10.1091/mbc.E04-06-0508",
language = "English (US)",
volume = "16",
pages = "279--291",
journal = "Molecular Biology of the Cell",
issn = "1059-1524",
publisher = "American Society for Cell Biology",
number = "1",

}

TY - JOUR

T1 - The efficiency of protein compartmentalization into the secretory pathway

AU - Levine, Corinna

AU - Mitra, Devarati

AU - Sharma, Ajay

AU - Smith, Carolyn L.

AU - Hegde, Ramanujan S.

PY - 2005/1

Y1 - 2005/1

N2 - Numerous proteins targeted for the secretory pathway are increasingly implicated in functional or pathological roles at alternative cellular destinations. The parameters that allow secretory or membrane proteins to reside in intracellular locales outside the secretory pathway remain largely unexplored. In this study, we have used an extremely sensitive and quantitative assay to measure the in vivo efficiency of signal sequence-mediated protein segregation into the secretory pathway. Our findings reveal that segregation efficiency varies tremendously among signals, ranging from >95 to

AB - Numerous proteins targeted for the secretory pathway are increasingly implicated in functional or pathological roles at alternative cellular destinations. The parameters that allow secretory or membrane proteins to reside in intracellular locales outside the secretory pathway remain largely unexplored. In this study, we have used an extremely sensitive and quantitative assay to measure the in vivo efficiency of signal sequence-mediated protein segregation into the secretory pathway. Our findings reveal that segregation efficiency varies tremendously among signals, ranging from >95 to

UR - http://www.scopus.com/inward/record.url?scp=11144255136&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11144255136&partnerID=8YFLogxK

U2 - 10.1091/mbc.E04-06-0508

DO - 10.1091/mbc.E04-06-0508

M3 - Article

C2 - 15496459

AN - SCOPUS:11144255136

VL - 16

SP - 279

EP - 291

JO - Molecular Biology of the Cell

JF - Molecular Biology of the Cell

SN - 1059-1524

IS - 1

ER -