The efficacy of IL-3, SCF, IL-6, and IL-11 in treating thrombocytopenia

P. Maslak, S. D. Nimer

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Suppression of normal hematopoiesis is a frequent complication of cancer or its treatment. The basis for dose-intensified cancer therapy in the 1990s was the discovery that hematopoietic growth factors and peripheral blood progenitor cell infusions can ameliorate some of its associated hematologic toxicities. Both granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor accelerate neutrophil recovery after chemotherapy and can mobilize peripheral blood progenitor cells for use in autologous or allogeneic transplantation. Unfortunately, the duration and severity of chemotherapy-induced thrombocytopenia is unaffected by the use of these myeloid growth factors. During the last 5 years, the activities of a variety of potential platelet or megakaryocyte-stimulating factors have been determined in clinical trials. The results of these studies are described.

Original languageEnglish (US)
Pages (from-to)253-260
Number of pages8
JournalSeminars in Hematology
Volume35
Issue number3
StatePublished - Jul 31 1998
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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