The Effects of Various Antihypertensive Agents on Cardiovascular Risk Factors in Patients With Renal Failure

Mario Zarama, Leopoldo Raij

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Systemic cardiovascular diseases are the most important cause of morbidity and mortality among patients with chronic renal failure. Hypertension, lipid-profile abnormalities, glucose intolerance, and left ventricular hypertrophy are found in most patients with chronic renal failure and are responsible for the increased incidence of atherosclerosis. Hypertension is the risk factor most susceptible to treatment, but consideration must be given in selecting an antihypertensive agent not only to its effect on blood pressure but to its effects on the other risk factors. Improper selection could impair the long-term benefit of good blood pressure control by increasing the severity of the other cardiovascular risk factors and eventually worsening the prognosis of the chronic renal failure. The remaining renal function in patients not yet in end-stage renal failure deserves special consideration; an adequate antihypertensive regimen could potentially delay the need for dialysis.

Original languageEnglish (US)
Pages (from-to)100-107
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume21
Issue number5
DOIs
StatePublished - Jan 1 1993

Keywords

  • Cardiovascular risk factors
  • Chronic renal failure
  • Dyslipidemia
  • Glucose intolerance
  • Hypertension
  • Left ventricular hypertrophy

ASJC Scopus subject areas

  • Nephrology

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