Deep candidosis was established in healthy uncompromised Wistar rats by injecting Candida albicans into the right internal carotid artery. Death of these animals could be produced within seven days by injecting 107 yeasts. The kidneys were most severely infected and the entire brain was involved. No animal demonstrated leptomeningitis. Within one to two days microabscesses developed, subsiding into a histiocytic response in five to seven days. By seven days, chronic inflammation with noncaseating granulomas was seen. Throughout the study, cerebrospinal fluid and blood cultures failed to demonstrate the fungus. This rodent model is similar to human cerebral candidosis.
|Original language||English (US)|
|Number of pages||5|
|State||Published - 1979|
ASJC Scopus subject areas
- Clinical Neurology