The effects of topical vitamin K on bruising after laser treatment

Neha S. Shah, Melissa C. Lazarus, Reimo Bugdodel, Sung L. Hsia, Jinlin He, Robert Duncan, Leslie Baumann

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Background: Pulsed dye laser treatment and other cosmetic procedures result in significant bruising. Claims have been made regarding the efficacy of topical vitamin K in both preventing and speeding the clearing of bruising; however, well-controlled studies are lacking. Objective: The purpose of this study is to evaluate the effects of topical vitamin K versus placebo in the prevention and clearing of laser-induced purpura. Methods: A total of 22 patients were enrolled in this double-blind randomized placebo-controlled study. The patients were divided into pretreatment and posttreatment groups; the 11 patients in the former group applied vitamin K cream to half of their face and vehicle alone to the other half of their face twice daily for 2 weeks before laser treatment. The latter group followed the same procedure for 2 weeks after laser treatment. On day 0, all subjects underwent laser treatment for facial telangiectases using a 585-nm pulsed dye laser. Bruising was rated by the both the patient and physician by means of a visual analogue scale on days 0, 3, 7, 10, 14, and 17. Results: The side of the face treated with topical vitamin K before laser therapy showed no significant difference in bruising as compared to placebo. However, the side of the face treated with vitamin K cream after laser treatment had significantly lower scores of bruising severity when compared with the side treated with placebo. Conclusion: Although pretreatment with vitamin K did not prevent bruising after laser treatment, use of vitamin K cream after laser treatment did reduce the severity of bruising, particularly in the initial days of application.

Original languageEnglish (US)
Pages (from-to)241-244
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume47
Issue number2
DOIs
StatePublished - Aug 1 2002

ASJC Scopus subject areas

  • Dermatology

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    Shah, N. S., Lazarus, M. C., Bugdodel, R., Hsia, S. L., He, J., Duncan, R., & Baumann, L. (2002). The effects of topical vitamin K on bruising after laser treatment. Journal of the American Academy of Dermatology, 47(2), 241-244. https://doi.org/10.1067/mjd.2002.120465