The effects of thyroid state on beta-adrenergic and serotonergic receptors in rat brain

George A. Mason, Stephen C. Bondy, Charles Nemeroff, Cheryl H. Walker, Arthur J. Prange

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

The effects of hyperthyroidism or hypothyroidism, alone or in combination with the tricyclic antidepressant desmethylimipramine (DMI), on brain beta-adrenergic and serotonin (5HT2) receptors were studied in adult male Sprague-Dawley rats. Intraperitoneal administration of T3 or T4 for 7 days increased the number of cortical beta-adrenergic and 5HT2 receptors. These increases were significant at levels of 250 μg/kg or above for both hormones. Neither thyroidectomy nor "reverse" T3 (rT3) (500 μg/kg) produced an effect on either receptor type. The down-regulation of beta-adrenergic receptors produced by daily subcutaneous injections of 20 mg/kg of DMI for 7 days was partially offset by concurrent administration of T4, whereas the down-regulation of 5HT2 receptors produced by the drug was not affected by concurrent administration of either T3 or T4. Hypothyroidism (thyroidectomy) did not significantly affect the adaptation of these receptor populations to DMI. As regards brain regions other than cortex, T4 (250 μg/kg) produced the same changes in hippocampus as in cortex, while thyroidectomy decreased beta-adrenergic receptors only in the cerebellum. Thyroxine also elevated 5HT2 receptors in the hippocampus; thyroidectomy caused a significant decrease in 5HT2 receptors in the striatum.

Original languageEnglish
Pages (from-to)261-270
Number of pages10
JournalPsychoneuroendocrinology
Volume12
Issue number4
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

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Receptors, Adrenergic, beta
Thyroidectomy
Desipramine
Thyroid Gland
Brain
Hypothyroidism
Hippocampus
Down-Regulation
Tricyclic Antidepressive Agents
Serotonin Receptors
Hyperthyroidism
Subcutaneous Injections
Thyroxine
Adrenergic Agents
Cerebellum
Sprague Dawley Rats
Hormones
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems
  • Psychology(all)

Cite this

The effects of thyroid state on beta-adrenergic and serotonergic receptors in rat brain. / Mason, George A.; Bondy, Stephen C.; Nemeroff, Charles; Walker, Cheryl H.; Prange, Arthur J.

In: Psychoneuroendocrinology, Vol. 12, No. 4, 01.01.1987, p. 261-270.

Research output: Contribution to journalArticle

Mason, George A. ; Bondy, Stephen C. ; Nemeroff, Charles ; Walker, Cheryl H. ; Prange, Arthur J. / The effects of thyroid state on beta-adrenergic and serotonergic receptors in rat brain. In: Psychoneuroendocrinology. 1987 ; Vol. 12, No. 4. pp. 261-270.
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