The effects of the anorexigenic peptide pyro-Glu-His-Gly-OH on the sleep cycle

J. R. Calle, J. Espinar-Sierra, M. A. Rubio, A. Vela-Bueno, A. V. Schally, A. L. Charro

Research output: Contribution to journalArticle

Abstract

The tripeptide pyro-Glu-His-Gly-OH is a new anorexigenic substance, isolated from the urine of patients with anorexia nervosa. In this study the effects on sleep of this anorexigenic peptide were evaluated. Sleep was polygraphically recorded in four healthy volunteers on three consecutive nights. Amphetamine-like effects on sleep were noted in three subjects after infusion of pyro-Glu-His-Gly-OH on the third night with total wake time showing an increase and REM percent a decrease.

Original languageEnglish (US)
Pages (from-to)61-71
Number of pages11
JournalResearch Communications in Psychology, Psychiatry and Behavior
Volume14
Issue number1
StatePublished - Jan 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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  • Cite this

    Calle, J. R., Espinar-Sierra, J., Rubio, M. A., Vela-Bueno, A., Schally, A. V., & Charro, A. L. (1989). The effects of the anorexigenic peptide pyro-Glu-His-Gly-OH on the sleep cycle. Research Communications in Psychology, Psychiatry and Behavior, 14(1), 61-71.