The effects of somatostatin and metiamide on tachyphylaxis of pentagastrin stimulated gastric acid and pepsin secretion in the conscious cat

M. Albinus, E. L. Blair, B. H. Hirst, J. D. Reed, Andrew V Schally, B. Shaw

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Pentagastrin stimulated gastric acid and pepsin secretions show parallel rates of tachyphylaxis in the conscious cat. The responses to histamine show only slight tachyphylaxis. Somatostatin 10 μg.kg -1.hr -1 inhibits pentagastrin but not histamine stimulated acid secretion and inhibits pentagastrin stimulated pepsin secretion. The inhibition of pentagastrin stimulated acid and pepsin secretion by Somatostatin delays the tachyphylaxis of these responses, but the rates of tachyphylaxis when they do subsequently occur are identical. Metiamide 10 mg.kg -1.hr -1 equally inhibits histamine and pentagastrin stimulated acid secretion but does not inhibit pentagastrin stimulated pepsin secretion. Inhibition of acid secretion during metiamide infusion neither prevents nor delays acid nor pepsin tachyphylaxis. It is suggested that tachyphylaxis of acid and pepsin secretion is a gastrin receptor phenomenon and that Somatostatin occupies or modifies the behavior of these receptors, preventing tachyphylaxis. Metiamide, however, exerts its action only on the histamine H 2 receptor and not the gastrin receptor mechanism, and this apparently does not prevent or delay acid tachyphylaxis.

Original languageEnglish
Pages (from-to)801-817
Number of pages17
JournalJournal of Physiology
Volume266
Issue number3
StatePublished - Nov 6 1977
Externally publishedYes

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Metiamide
Tachyphylaxis
Pentagastrin
Pepsin A
Gastric Acid
Somatostatin
Cats
Acids
Histamine
Cholecystokinin B Receptor

ASJC Scopus subject areas

  • Physiology

Cite this

The effects of somatostatin and metiamide on tachyphylaxis of pentagastrin stimulated gastric acid and pepsin secretion in the conscious cat. / Albinus, M.; Blair, E. L.; Hirst, B. H.; Reed, J. D.; Schally, Andrew V; Shaw, B.

In: Journal of Physiology, Vol. 266, No. 3, 06.11.1977, p. 801-817.

Research output: Contribution to journalArticle

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AU - Shaw, B.

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AB - Pentagastrin stimulated gastric acid and pepsin secretions show parallel rates of tachyphylaxis in the conscious cat. The responses to histamine show only slight tachyphylaxis. Somatostatin 10 μg.kg -1.hr -1 inhibits pentagastrin but not histamine stimulated acid secretion and inhibits pentagastrin stimulated pepsin secretion. The inhibition of pentagastrin stimulated acid and pepsin secretion by Somatostatin delays the tachyphylaxis of these responses, but the rates of tachyphylaxis when they do subsequently occur are identical. Metiamide 10 mg.kg -1.hr -1 equally inhibits histamine and pentagastrin stimulated acid secretion but does not inhibit pentagastrin stimulated pepsin secretion. Inhibition of acid secretion during metiamide infusion neither prevents nor delays acid nor pepsin tachyphylaxis. It is suggested that tachyphylaxis of acid and pepsin secretion is a gastrin receptor phenomenon and that Somatostatin occupies or modifies the behavior of these receptors, preventing tachyphylaxis. Metiamide, however, exerts its action only on the histamine H 2 receptor and not the gastrin receptor mechanism, and this apparently does not prevent or delay acid tachyphylaxis.

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