The effects of radiation on the immune response: a review

Arnold Markoe, P. H. Saluk

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This review discusses the effects of ionizing radiation on the immune system and on the various immune responses, with emphasis on the human experience. The differential radiosensitivity of the various cellular components of the immune system is discussed and related to the interpretation of radiation effects on the antibody response and on the cell-mediated immune response. Lymphocyte traffic is discussed as a basis for differentiation between total-body and regional radiation effects and between acute and fractionated radiation exposure. Wherever possible, information from relevant literature has been collated into a conceptual framework, allowing for presentation of current controversies and for concise delineation of areas of broad agreement. Also explored are problems encountered in utilizing data obtained from a human population that may be altered immunologically by malignant disease.

Original languageEnglish
Pages (from-to)63-72+122
JournalApplied Radiology
Volume6
Issue number5
StatePublished - Dec 1 1977
Externally publishedYes

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Radiation Effects
Immune System
Radiation Tolerance
Ionizing Radiation
Antibody Formation
Lymphocytes
Population
Radiation Exposure

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

The effects of radiation on the immune response : a review. / Markoe, Arnold; Saluk, P. H.

In: Applied Radiology, Vol. 6, No. 5, 01.12.1977, p. 63-72+122.

Research output: Contribution to journalArticle

Markoe, Arnold ; Saluk, P. H. / The effects of radiation on the immune response : a review. In: Applied Radiology. 1977 ; Vol. 6, No. 5. pp. 63-72+122.
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