The effects of radiation on the immune response: a review

A. M. Markoe, P. H. Saluk

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

This review discusses the effects of ionizing radiation on the immune system and on the various immune responses, with emphasis on the human experience. The differential radiosensitivity of the various cellular components of the immune system is discussed and related to the interpretation of radiation effects on the antibody response and on the cell-mediated immune response. Lymphocyte traffic is discussed as a basis for differentiation between total-body and regional radiation effects and between acute and fractionated radiation exposure. Wherever possible, information from relevant literature has been collated into a conceptual framework, allowing for presentation of current controversies and for concise delineation of areas of broad agreement. Also explored are problems encountered in utilizing data obtained from a human population that may be altered immunologically by malignant disease.

Original languageEnglish (US)
Pages (from-to)63-72+122
JournalApplied Radiology
Volume6
Issue number5
StatePublished - Jan 1 1977
Externally publishedYes

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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