The effects of phenylephrine 2.5% versus phenylephrine 10% on pupillary dilation in patients with diabetes

Jayne S. Weiss, Jeffrey N. Weiss, David S. Greenfield

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Purpose: A prospective, double-blind study was conducted to compare the clinical efficacy of a combination of 1% tropicamide and 2.5% phenylephrine and a combination of 1% tropicamide and 10% phenylephrine for pupillary dilation in patients with diabetes. Methods: Either 2.5% phenylephrine in one eye and 10% phenylephrine in the other eye, 2.5% phenylephrine in both eyes, or 10% phenylephrine in both eyes was administered to 127 consecutive patients with diabetes. All patients received 1% tropicamide in both eyes. Results: There was no statistically significant difference in the amount of pupillary dilation between the three groups. Conclusion: As 2.5% phenylephrine may produce a lower incidence of side effects than the 10% concentration, we advise the use of the lower concentration, particularly among patients with diabetes, who already exhibit a higher prevalence of vascular disease and autonomic dysfunction.

Original languageEnglish (US)
Pages (from-to)130-133
Number of pages4
JournalRetina
Volume15
Issue number2
DOIs
StatePublished - Jan 1 1995

Keywords

  • Diabetes
  • Mydriasis
  • Phenylephrine
  • Pupillary dilation

ASJC Scopus subject areas

  • Ophthalmology

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