The effects of neurotensin, β-endorphin and bombesin on ethanol-induced behaviors in mice

Daniel Luttinger, Gerald D. Frye, Charles B. Nemeroff, Arthur J. Prange

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The effects of the three peptides neurotensin, β-endorphin, and bombesin on ethanol-induced behaviors were studied in mice. Intracisternal administration of these peptides to mice prolonged the duration of sleep induced by ethanol (5.2 g/kg). Neurotensin and β-endorphin also enhanced thanol-induced hypothermia. None of the peptides, when administered alone, produced sleep. Lowever, all three compounds impaired the aerial righting reflex and induced sleep when followed by an IP dose of ethanol (3.5 g/kg), which alone did not induce sleep. These results, taken together with previous findings, suggest that neuropeptides may be involved in the complex mechanisms of action of ethanol on the CNS.

Original languageEnglish (US)
Pages (from-to)357-363
Number of pages7
JournalPsychopharmacology
Volume79
Issue number4
DOIs
StatePublished - Mar 1 1983
Externally publishedYes

Keywords

  • β-Endorphin
  • Bombesin
  • Ethanol
  • Neurotensin
  • Thyrotropin-releasing hormone

ASJC Scopus subject areas

  • Pharmacology

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