Abstract
The effects of the three peptides neurotensin, β-endorphin, and bombesin on ethanol-induced behaviors were studied in mice. Intracisternal administration of these peptides to mice prolonged the duration of sleep induced by ethanol (5.2 g/kg). Neurotensin and β-endorphin also enhanced thanol-induced hypothermia. None of the peptides, when administered alone, produced sleep. Lowever, all three compounds impaired the aerial righting reflex and induced sleep when followed by an IP dose of ethanol (3.5 g/kg), which alone did not induce sleep. These results, taken together with previous findings, suggest that neuropeptides may be involved in the complex mechanisms of action of ethanol on the CNS.
| Original language | English |
|---|---|
| Pages (from-to) | 357-363 |
| Number of pages | 7 |
| Journal | Psychopharmacology |
| Volume | 79 |
| Issue number | 4 |
| DOIs | |
| State | Published - Mar 1 1983 |
| Externally published | Yes |
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Keywords
- β-Endorphin
- Bombesin
- Ethanol
- Neurotensin
- Thyrotropin-releasing hormone
ASJC Scopus subject areas
- Pharmacology
Cite this
The effects of neurotensin, β-endorphin and bombesin on ethanol-induced behaviors in mice. / Luttinger, Daniel; Frye, Gerald D.; Nemeroff, Charles; Prange, Arthur J.
In: Psychopharmacology, Vol. 79, No. 4, 01.03.1983, p. 357-363.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effects of neurotensin, β-endorphin and bombesin on ethanol-induced behaviors in mice
AU - Luttinger, Daniel
AU - Frye, Gerald D.
AU - Nemeroff, Charles
AU - Prange, Arthur J.
PY - 1983/3/1
Y1 - 1983/3/1
N2 - The effects of the three peptides neurotensin, β-endorphin, and bombesin on ethanol-induced behaviors were studied in mice. Intracisternal administration of these peptides to mice prolonged the duration of sleep induced by ethanol (5.2 g/kg). Neurotensin and β-endorphin also enhanced thanol-induced hypothermia. None of the peptides, when administered alone, produced sleep. Lowever, all three compounds impaired the aerial righting reflex and induced sleep when followed by an IP dose of ethanol (3.5 g/kg), which alone did not induce sleep. These results, taken together with previous findings, suggest that neuropeptides may be involved in the complex mechanisms of action of ethanol on the CNS.
AB - The effects of the three peptides neurotensin, β-endorphin, and bombesin on ethanol-induced behaviors were studied in mice. Intracisternal administration of these peptides to mice prolonged the duration of sleep induced by ethanol (5.2 g/kg). Neurotensin and β-endorphin also enhanced thanol-induced hypothermia. None of the peptides, when administered alone, produced sleep. Lowever, all three compounds impaired the aerial righting reflex and induced sleep when followed by an IP dose of ethanol (3.5 g/kg), which alone did not induce sleep. These results, taken together with previous findings, suggest that neuropeptides may be involved in the complex mechanisms of action of ethanol on the CNS.
KW - β-Endorphin
KW - Bombesin
KW - Ethanol
KW - Neurotensin
KW - Thyrotropin-releasing hormone
UR - http://www.scopus.com/inward/record.url?scp=0020526919&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020526919&partnerID=8YFLogxK
U2 - 10.1007/BF00433418
DO - 10.1007/BF00433418
M3 - Article
C2 - 6304802
AN - SCOPUS:0020526919
VL - 79
SP - 357
EP - 363
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 4
ER -