The effects of ionizing radiation on the dividing cells of the conjunctival epithelium

R. Mitrani, B. V. Worgul

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The influence of an X-ray dose of 10 Gy (1000 rads) on mitosis in the rat conjunctival epithelium was assessed. A mitotic inhibition began 1 hour postirradiation and continued for 4 days. The mitotic index was depressed to 10% of control values. After 5 days postirradiation, the mitotic index surpassed the control values peaking at 7 days postirradiation. The spindle axes of cells in telophase of the perilimbal rat conjunctival epithelium assume a characteristic, three dimensional orientation relative to the limbus. Ionizing radiation did not disrupt this organization at any time postirradiation. In fact, the frequency of mitotic figures preferentially aligned in irradiated tissue was enhanced during the mitotic rebound.

Original languageEnglish (US)
Pages (from-to)523-528
Number of pages6
JournalCurrent Eye Research
Volume5
Issue number7
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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