The effects of interictal spikes on single neuron firing patterns in the hippocampus during the development of temporal lobe epilepsy

Wenjuan Yan, Jeremiah D. Mitzelfelt, Jose C. Príncipe, Justin C. Sanchez

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The interictal spikes (IS) are characteristic signatures of epileptic tissue, and relevant in presurgical evaluation of epilepsy. However, the mechanism and effects of IS remain unclear. In this study, we examined the relationship between IS and single neuron firing patterns, using an epileptic rat with temporal lobe epilepsy (TLE). We investigated the firing of interneurons and pyramidal cells in the CA3 region of the hippocampus. The results show that IS are associated with decreased single neuron firing rates compared with IS-free epochs. Furthermore, the paroxysmal interictal-spiking patterns are associated with sustained decrease in single neuron firing rates. We also found that IS stopped as approaching to seizures. These results demonstrate that IS might be responsible for the development of TLE and ictal events by changing the firing patterns of hippocampal neurons.

Original languageEnglish
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"
Pages4134-4137
Number of pages4
StatePublished - Dec 1 2008
Externally publishedYes
Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada
Duration: Aug 20 2008Aug 25 2008

Other

Other30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
CountryCanada
CityVancouver, BC
Period8/20/088/25/08

Fingerprint

Temporal Lobe Epilepsy
Neurons
Hippocampus
Pyramidal Cells
Interneurons
Rats
Epilepsy
Seizures
Stroke
Tissue

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Yan, W., Mitzelfelt, J. D., Príncipe, J. C., & Sanchez, J. C. (2008). The effects of interictal spikes on single neuron firing patterns in the hippocampus during the development of temporal lobe epilepsy. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology" (pp. 4134-4137). [4650119]

The effects of interictal spikes on single neuron firing patterns in the hippocampus during the development of temporal lobe epilepsy. / Yan, Wenjuan; Mitzelfelt, Jeremiah D.; Príncipe, Jose C.; Sanchez, Justin C.

Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology". 2008. p. 4134-4137 4650119.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yan, W, Mitzelfelt, JD, Príncipe, JC & Sanchez, JC 2008, The effects of interictal spikes on single neuron firing patterns in the hippocampus during the development of temporal lobe epilepsy. in Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"., 4650119, pp. 4134-4137, 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08, Vancouver, BC, Canada, 8/20/08.
Yan W, Mitzelfelt JD, Príncipe JC, Sanchez JC. The effects of interictal spikes on single neuron firing patterns in the hippocampus during the development of temporal lobe epilepsy. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology". 2008. p. 4134-4137. 4650119
Yan, Wenjuan ; Mitzelfelt, Jeremiah D. ; Príncipe, Jose C. ; Sanchez, Justin C. / The effects of interictal spikes on single neuron firing patterns in the hippocampus during the development of temporal lobe epilepsy. Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology". 2008. pp. 4134-4137
@inproceedings{5643d63a20d44052b5ea193a7d2a207f,
title = "The effects of interictal spikes on single neuron firing patterns in the hippocampus during the development of temporal lobe epilepsy",
abstract = "The interictal spikes (IS) are characteristic signatures of epileptic tissue, and relevant in presurgical evaluation of epilepsy. However, the mechanism and effects of IS remain unclear. In this study, we examined the relationship between IS and single neuron firing patterns, using an epileptic rat with temporal lobe epilepsy (TLE). We investigated the firing of interneurons and pyramidal cells in the CA3 region of the hippocampus. The results show that IS are associated with decreased single neuron firing rates compared with IS-free epochs. Furthermore, the paroxysmal interictal-spiking patterns are associated with sustained decrease in single neuron firing rates. We also found that IS stopped as approaching to seizures. These results demonstrate that IS might be responsible for the development of TLE and ictal events by changing the firing patterns of hippocampal neurons.",
author = "Wenjuan Yan and Mitzelfelt, {Jeremiah D.} and Pr{\'i}ncipe, {Jose C.} and Sanchez, {Justin C.}",
year = "2008",
month = "12",
day = "1",
language = "English",
isbn = "9781424418152",
pages = "4134--4137",
booktitle = "Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - {"}Personalized Healthcare through Technology{"}",

}

TY - GEN

T1 - The effects of interictal spikes on single neuron firing patterns in the hippocampus during the development of temporal lobe epilepsy

AU - Yan, Wenjuan

AU - Mitzelfelt, Jeremiah D.

AU - Príncipe, Jose C.

AU - Sanchez, Justin C.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - The interictal spikes (IS) are characteristic signatures of epileptic tissue, and relevant in presurgical evaluation of epilepsy. However, the mechanism and effects of IS remain unclear. In this study, we examined the relationship between IS and single neuron firing patterns, using an epileptic rat with temporal lobe epilepsy (TLE). We investigated the firing of interneurons and pyramidal cells in the CA3 region of the hippocampus. The results show that IS are associated with decreased single neuron firing rates compared with IS-free epochs. Furthermore, the paroxysmal interictal-spiking patterns are associated with sustained decrease in single neuron firing rates. We also found that IS stopped as approaching to seizures. These results demonstrate that IS might be responsible for the development of TLE and ictal events by changing the firing patterns of hippocampal neurons.

AB - The interictal spikes (IS) are characteristic signatures of epileptic tissue, and relevant in presurgical evaluation of epilepsy. However, the mechanism and effects of IS remain unclear. In this study, we examined the relationship between IS and single neuron firing patterns, using an epileptic rat with temporal lobe epilepsy (TLE). We investigated the firing of interneurons and pyramidal cells in the CA3 region of the hippocampus. The results show that IS are associated with decreased single neuron firing rates compared with IS-free epochs. Furthermore, the paroxysmal interictal-spiking patterns are associated with sustained decrease in single neuron firing rates. We also found that IS stopped as approaching to seizures. These results demonstrate that IS might be responsible for the development of TLE and ictal events by changing the firing patterns of hippocampal neurons.

UR - http://www.scopus.com/inward/record.url?scp=61949087058&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61949087058&partnerID=8YFLogxK

M3 - Conference contribution

SN - 9781424418152

SP - 4134

EP - 4137

BT - Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"

ER -