The effects of interictal spikes on single neuron firing patterns in the hippocampus during the development of temporal lobe epilepsy

Wenjuan Yan, Jeremiah D. Mitzelfelt, Jose C. Príncipe, Justin C. Sanchez

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

The interictal spikes (IS) are characteristic signatures of epileptic tissue, and relevant in presurgical evaluation of epilepsy. However, the mechanism and effects of IS remain unclear. In this study, we examined the relationship between IS and single neuron firing patterns, using an epileptic rat with temporal lobe epilepsy (TLE). We investigated the firing of interneurons and pyramidal cells in the CA3 region of the hippocampus. The results show that IS are associated with decreased single neuron firing rates compared with IS-free epochs. Furthermore, the paroxysmal interictal-spiking patterns are associated with sustained decrease in single neuron firing rates. We also found that IS stopped as approaching to seizures. These results demonstrate that IS might be responsible for the development of TLE and ictal events by changing the firing patterns of hippocampal neurons.

Original languageEnglish (US)
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
Pages4134-4137
Number of pages4
StatePublished - Dec 1 2008
Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada
Duration: Aug 20 2008Aug 25 2008

Publication series

NameProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"

Other

Other30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
CountryCanada
CityVancouver, BC
Period8/20/088/25/08

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ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Yan, W., Mitzelfelt, J. D., Príncipe, J. C., & Sanchez, J. C. (2008). The effects of interictal spikes on single neuron firing patterns in the hippocampus during the development of temporal lobe epilepsy. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 (pp. 4134-4137). [4650119] (Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology").