The effects of insulin-like growth factor-1 on critical-size calvarial defects in Sprague-Dawley rats

Seth Thaller, A. Dart, H. Tesluk

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

In a previous study prepared in 1992, we found that insulin-like growth factor-1 showed promise in hastening intramembranous bone repair in midfacial bone defects. For the present study, we created critical-size calvarial defects in 36 adult male Sprague-Dawley rats. The rats were then divided into two groups and killed at 1, 2, 3, 4, 5, 6, and 8 weeks. Twenty-one rats were administered insulin-like growth factor-1 subcutaneously with a 14-day osmotic infusion pump. An untreated group served as controls. Results were compared using routine histology to examine bone reconstitution of the surgical defects. Within the experimental group, we observed repair commenced at ~1 week and the critical-size calvarial bone defects were completely obliterated by 6 weeks; in the control group, even by 8 weeks, the surgical defects remained almost unchanged. In summary, this is further evidence that insulin-like growth factor-1 may have the potential to accelerate repair of intramembranous bone defects.

Original languageEnglish
Pages (from-to)429-433
Number of pages5
JournalAnnals of Plastic Surgery
Volume31
Issue number5
DOIs
StatePublished - Nov 23 1993
Externally publishedYes

Fingerprint

Somatomedins
Sprague Dawley Rats
Bone and Bones
Infusion Pumps
Histology
Control Groups

ASJC Scopus subject areas

  • Surgery

Cite this

The effects of insulin-like growth factor-1 on critical-size calvarial defects in Sprague-Dawley rats. / Thaller, Seth; Dart, A.; Tesluk, H.

In: Annals of Plastic Surgery, Vol. 31, No. 5, 23.11.1993, p. 429-433.

Research output: Contribution to journalArticle

@article{0b070bb39e1847fa8c4b20c3283bba61,
title = "The effects of insulin-like growth factor-1 on critical-size calvarial defects in Sprague-Dawley rats",
abstract = "In a previous study prepared in 1992, we found that insulin-like growth factor-1 showed promise in hastening intramembranous bone repair in midfacial bone defects. For the present study, we created critical-size calvarial defects in 36 adult male Sprague-Dawley rats. The rats were then divided into two groups and killed at 1, 2, 3, 4, 5, 6, and 8 weeks. Twenty-one rats were administered insulin-like growth factor-1 subcutaneously with a 14-day osmotic infusion pump. An untreated group served as controls. Results were compared using routine histology to examine bone reconstitution of the surgical defects. Within the experimental group, we observed repair commenced at ~1 week and the critical-size calvarial bone defects were completely obliterated by 6 weeks; in the control group, even by 8 weeks, the surgical defects remained almost unchanged. In summary, this is further evidence that insulin-like growth factor-1 may have the potential to accelerate repair of intramembranous bone defects.",
author = "Seth Thaller and A. Dart and H. Tesluk",
year = "1993",
month = "11",
day = "23",
doi = "10.1097/00000637-199311000-00007",
language = "English",
volume = "31",
pages = "429--433",
journal = "Annals of Plastic Surgery",
issn = "0148-7043",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - The effects of insulin-like growth factor-1 on critical-size calvarial defects in Sprague-Dawley rats

AU - Thaller, Seth

AU - Dart, A.

AU - Tesluk, H.

PY - 1993/11/23

Y1 - 1993/11/23

N2 - In a previous study prepared in 1992, we found that insulin-like growth factor-1 showed promise in hastening intramembranous bone repair in midfacial bone defects. For the present study, we created critical-size calvarial defects in 36 adult male Sprague-Dawley rats. The rats were then divided into two groups and killed at 1, 2, 3, 4, 5, 6, and 8 weeks. Twenty-one rats were administered insulin-like growth factor-1 subcutaneously with a 14-day osmotic infusion pump. An untreated group served as controls. Results were compared using routine histology to examine bone reconstitution of the surgical defects. Within the experimental group, we observed repair commenced at ~1 week and the critical-size calvarial bone defects were completely obliterated by 6 weeks; in the control group, even by 8 weeks, the surgical defects remained almost unchanged. In summary, this is further evidence that insulin-like growth factor-1 may have the potential to accelerate repair of intramembranous bone defects.

AB - In a previous study prepared in 1992, we found that insulin-like growth factor-1 showed promise in hastening intramembranous bone repair in midfacial bone defects. For the present study, we created critical-size calvarial defects in 36 adult male Sprague-Dawley rats. The rats were then divided into two groups and killed at 1, 2, 3, 4, 5, 6, and 8 weeks. Twenty-one rats were administered insulin-like growth factor-1 subcutaneously with a 14-day osmotic infusion pump. An untreated group served as controls. Results were compared using routine histology to examine bone reconstitution of the surgical defects. Within the experimental group, we observed repair commenced at ~1 week and the critical-size calvarial bone defects were completely obliterated by 6 weeks; in the control group, even by 8 weeks, the surgical defects remained almost unchanged. In summary, this is further evidence that insulin-like growth factor-1 may have the potential to accelerate repair of intramembranous bone defects.

UR - http://www.scopus.com/inward/record.url?scp=0027436260&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027436260&partnerID=8YFLogxK

U2 - 10.1097/00000637-199311000-00007

DO - 10.1097/00000637-199311000-00007

M3 - Article

C2 - 8285528

AN - SCOPUS:0027436260

VL - 31

SP - 429

EP - 433

JO - Annals of Plastic Surgery

JF - Annals of Plastic Surgery

SN - 0148-7043

IS - 5

ER -