Abstract
In a previous study prepared in 1992, we found that insulin-like growth factor-1 showed promise in hastening intramembranous bone repair in midfacial bone defects. For the present study, we created critical-size calvarial defects in 36 adult male Sprague-Dawley rats. The rats were then divided into two groups and killed at 1, 2, 3, 4, 5, 6, and 8 weeks. Twenty-one rats were administered insulin-like growth factor-1 subcutaneously with a 14-day osmotic infusion pump. An untreated group served as controls. Results were compared using routine histology to examine bone reconstitution of the surgical defects. Within the experimental group, we observed repair commenced at ~1 week and the critical-size calvarial bone defects were completely obliterated by 6 weeks; in the control group, even by 8 weeks, the surgical defects remained almost unchanged. In summary, this is further evidence that insulin-like growth factor-1 may have the potential to accelerate repair of intramembranous bone defects.
| Original language | English |
|---|---|
| Pages (from-to) | 429-433 |
| Number of pages | 5 |
| Journal | Annals of Plastic Surgery |
| Volume | 31 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 23 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
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The effects of insulin-like growth factor-1 on critical-size calvarial defects in Sprague-Dawley rats. / Thaller, Seth; Dart, A.; Tesluk, H.
In: Annals of Plastic Surgery, Vol. 31, No. 5, 23.11.1993, p. 429-433.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effects of insulin-like growth factor-1 on critical-size calvarial defects in Sprague-Dawley rats
AU - Thaller, Seth
AU - Dart, A.
AU - Tesluk, H.
PY - 1993/11/23
Y1 - 1993/11/23
N2 - In a previous study prepared in 1992, we found that insulin-like growth factor-1 showed promise in hastening intramembranous bone repair in midfacial bone defects. For the present study, we created critical-size calvarial defects in 36 adult male Sprague-Dawley rats. The rats were then divided into two groups and killed at 1, 2, 3, 4, 5, 6, and 8 weeks. Twenty-one rats were administered insulin-like growth factor-1 subcutaneously with a 14-day osmotic infusion pump. An untreated group served as controls. Results were compared using routine histology to examine bone reconstitution of the surgical defects. Within the experimental group, we observed repair commenced at ~1 week and the critical-size calvarial bone defects were completely obliterated by 6 weeks; in the control group, even by 8 weeks, the surgical defects remained almost unchanged. In summary, this is further evidence that insulin-like growth factor-1 may have the potential to accelerate repair of intramembranous bone defects.
AB - In a previous study prepared in 1992, we found that insulin-like growth factor-1 showed promise in hastening intramembranous bone repair in midfacial bone defects. For the present study, we created critical-size calvarial defects in 36 adult male Sprague-Dawley rats. The rats were then divided into two groups and killed at 1, 2, 3, 4, 5, 6, and 8 weeks. Twenty-one rats were administered insulin-like growth factor-1 subcutaneously with a 14-day osmotic infusion pump. An untreated group served as controls. Results were compared using routine histology to examine bone reconstitution of the surgical defects. Within the experimental group, we observed repair commenced at ~1 week and the critical-size calvarial bone defects were completely obliterated by 6 weeks; in the control group, even by 8 weeks, the surgical defects remained almost unchanged. In summary, this is further evidence that insulin-like growth factor-1 may have the potential to accelerate repair of intramembranous bone defects.
UR - http://www.scopus.com/inward/record.url?scp=0027436260&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027436260&partnerID=8YFLogxK
U2 - 10.1097/00000637-199311000-00007
DO - 10.1097/00000637-199311000-00007
M3 - Article
C2 - 8285528
AN - SCOPUS:0027436260
VL - 31
SP - 429
EP - 433
JO - Annals of Plastic Surgery
JF - Annals of Plastic Surgery
SN - 0148-7043
IS - 5
ER -