The effects of glutamate receptor agonists on neurotensin release using in vivo microdialysis

James M. Radke, Michael J. Owens, Charles B. Nemeroff

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

In the study, extracellular concentrations of neurotensin were measured from the striatum, nucleus accumbens and the medial prefrontal cortex in the awake, freely moving rat. Using a highly sensitive solid phase radioimmunoassay, basal concentrations of neurotensin were 2-5 pg/sample. In each region, glutamate receptor agonists, N-methyl-D-aspartate (NMDA) and kainic acid, increased neurotensin release 2-3-fold. Preincubation with the Na+ channel blocker tetrodotoxin abolished the glutamate receptor agonist-induced increases except in the striatum following kainic acid infusion. These findings indicate that activation of glutamate receptors may indirectly stimulate neurotensin release.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalEuropean Journal of Pharmacology
Volume411
Issue number1-2
DOIs
StatePublished - Jan 10 2001
Externally publishedYes

Keywords

  • kainic acid
  • Medial prefontal cortex
  • NMDA (N-methyl-D-aspartate)
  • Nucleus accumbens
  • Striatum

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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