The Effects of Electroshock Convulsions on Calcium Transport within Synaptic Terminals

A. V. Delgado‐Escueta, S. Victor, D. Davidson

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Calcium transport was assessed within synaptic terminals isolated from cerebral cortices of rats which experienced one maximal electroshock (ES) convulsion daily. No significant change in calcium content [(Ca(i))] of synaptosomes was present after 2 consecutive days of maximal convulsions. After 4 and 6 days of maximal seizures, (Ca(i)) rose 20% and 37%, respectively. 45Ca2+ influx within synaptosomes in vitro increased after 6 days of ES convulsions (1.94 ± 0.4 μmol/g protein/min in ES convulsions versus 1.54 ± .03 μmol/g protein/min in controls). The higher rate of 45Ca2+ influx in convulsed animals was accounted for by elevated internal sodium [(Na(i))] values. Maximal 45Ca2+ efflux decreased after ES convulsions (0.48 μmol/g protein/min in ES convulsions versus 0.8 μmol/g protein/min in controls). The slower rate of 45Ca2+ efflux after convulsions was also accounted for by elevated (Na(i)). Our results suggest that (Ca(i)) increased within synapses after in vivo ES convulsions secondary to a primary ionic event, namely, elevated (Na(i)).

Original languageEnglish (US)
Pages (from-to)1140-1148
Number of pages9
JournalJournal of neurochemistry
Volume34
Issue number5
DOIs
StatePublished - May 1980
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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