The effects of chronic morphine treatment on neurotensin-induced antinociception

Daniel Luttinger, Susan K. Burgess, Charles B. Nemeroff, Arthur J. Prange

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Previous studies have shown that the opioid antagonist naloxone does not alter neurotensin (NT)-induced antinociception. In the present studies, tolerance to morphine in mice significantly attenuated NT-induced antinociception, but not NT-induced hypothermia. In addition, centrally administered NT inhibited naloxone-precipitated jumping in morphine-dependent mice. These results indicate complex interactions between NT-induced antinociception and opioid systems.

Original languageEnglish (US)
Pages (from-to)10-13
Number of pages4
Issue number1
StatePublished - Aug 1983
Externally publishedYes


  • Analgesia
  • Hypothermia
  • Morphine
  • Naloxone
  • Neurotensin
  • Tolerance

ASJC Scopus subject areas

  • Pharmacology


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