Abstract
Previous studies have shown that the opioid antagonist naloxone does not alter neurotensin (NT)-induced antinociception. In the present studies, tolerance to morphine in mice significantly attenuated NT-induced antinociception, but not NT-induced hypothermia. In addition, centrally administered NT inhibited naloxone-precipitated jumping in morphine-dependent mice. These results indicate complex interactions between NT-induced antinociception and opioid systems.
Original language | English (US) |
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Pages (from-to) | 10-13 |
Number of pages | 4 |
Journal | Psychopharmacology |
Volume | 81 |
Issue number | 1 |
DOIs | |
State | Published - Aug 1983 |
Externally published | Yes |
Keywords
- Analgesia
- Hypothermia
- Morphine
- Naloxone
- Neurotensin
- Tolerance
ASJC Scopus subject areas
- Pharmacology