The effects of chronic morphine treatment on neurotensin-induced antinociception

Daniel Luttinger; Susan K. Burgess; Charles B. Nemeroff; Arthur J. Prange

doi:10.1007/BF00439265

The effects of chronic morphine treatment on neurotensin-induced antinociception

Daniel Luttinger, Susan K. Burgess, Charles B. Nemeroff, Arthur J. Prange

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Previous studies have shown that the opioid antagonist naloxone does not alter neurotensin (NT)-induced antinociception. In the present studies, tolerance to morphine in mice significantly attenuated NT-induced antinociception, but not NT-induced hypothermia. In addition, centrally administered NT inhibited naloxone-precipitated jumping in morphine-dependent mice. These results indicate complex interactions between NT-induced antinociception and opioid systems.

Original language	English (US)
Pages (from-to)	10-13
Number of pages	4
Journal	Psychopharmacology
Volume	81
Issue number	1
DOIs	https://doi.org/10.1007/BF00439265
State	Published - Aug 1983
Externally published	Yes

Keywords

Analgesia
Hypothermia
Morphine
Naloxone
Neurotensin
Tolerance

ASJC Scopus subject areas

Pharmacology

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abstract = "Previous studies have shown that the opioid antagonist naloxone does not alter neurotensin (NT)-induced antinociception. In the present studies, tolerance to morphine in mice significantly attenuated NT-induced antinociception, but not NT-induced hypothermia. In addition, centrally administered NT inhibited naloxone-precipitated jumping in morphine-dependent mice. These results indicate complex interactions between NT-induced antinociception and opioid systems.",

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AU - Prange, Arthur J.

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AB - Previous studies have shown that the opioid antagonist naloxone does not alter neurotensin (NT)-induced antinociception. In the present studies, tolerance to morphine in mice significantly attenuated NT-induced antinociception, but not NT-induced hypothermia. In addition, centrally administered NT inhibited naloxone-precipitated jumping in morphine-dependent mice. These results indicate complex interactions between NT-induced antinociception and opioid systems.

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