The effects of chondroitinase ABC on the rabbit intervertebral disc. A roentgenographic and histologic study

J. A.C. Eurell, M. D. Brown, M. Ramos

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

A series of intradiscal injections of chondroitinase ABC was performed in 31 young adult rabbits. Roentgenograms were taken immediately postinjection and were repeated at two, three, five, six, seven, or nine days after injection. All had roentgenographic evidence of disc space narrowing at all stages after the injection. Histologic evaluation of safranin-O fast green-stained sections indicated degradation of proteoglycans in the annulus fibrosus of chondroitinase ABC-injected discs. The cells of the chondroitinase ABC-injected discs, the end plates, and the growth-plate areas of adjacent vertebral bodies appeared unaffected.

Original languageEnglish (US)
Pages (from-to)238-243
Number of pages6
JournalClinical orthopaedics and related research
Issue number256
StatePublished - Jan 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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