The effects of aloe vera on wound healing in cell proliferation, migration, and viability

Eric Teplicki, Qianli Ma, David E. Castillo, Mina Zarei, Adam P. Hustad, Juan Chen, Jie Li

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Introduction. Aloe vera is sometimes used as a folk remedy for minor wounds and burns, but its mechanisms of action in wound healing are unclear. Objective. In this study, the authors evaluate the effects of A vera on wound healing. Materials and Methods. In vitro analyses of cell proliferation and migration were conducted on normal human primary skin fibroblasts and keratinocytes in growth media with A vera solution and preservatives at various concentrations. Growth media with preservatives but without A vera solution served as the control. Results. Aloe vera had significant stimulatory effects on cell proliferation and migration of both fibroblasts and keratinocytes. Surprisingly, A vera also exhibited strong protective effects on preservative-induced keratinocyte death. Keratinocytes in the growth media with both the preservatives and A vera had dramatically higher viability than cells in the control media without A vera. Conclusions. The results suggest A vera accelerates wound healing by promoting the proliferation and migration of fibroblasts and keratinocytes and by protecting keratinocytes from preservative-induced death.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
Issue number9
StatePublished - Sep 1 2018


  • Aloe vera
  • Cell migration
  • Cell proliferation
  • Cell viability
  • Wound healing

ASJC Scopus subject areas

  • Surgery
  • Medical–Surgical


Dive into the research topics of 'The effects of aloe vera on wound healing in cell proliferation, migration, and viability'. Together they form a unique fingerprint.

Cite this