Abstract
A series of 6-alkyl-3β-benzyl-2-(methoxycarbonylmethyl)tropane analogues were synthesized and evaluated as cocaine binding-site ligands at the dopamine transporter (DAT). The in vitro inhibition of [3H]dopamine and the DAT binding affinity (K(i), [3H]WIN 35,428) were measured in rat caudate putamen tissue. Generally, substitution at the 6-position was found to reduce ligand potency.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 35-42 |
| Number of pages | 8 |
| Journal | Medicinal Chemistry Research |
| Volume | 8 |
| Issue number | 1-2 |
| State | Published - Jan 1 1998 |
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Organic Chemistry
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Lomenzo, S. A., Izenwasser, S., Katz, J. L., & Trudell, M. L. (1998). The effects of alkyl substituents at the 6-position of cocaine analogues on dopamine transporter binding affinity and dopamine uptake inhibition. Medicinal Chemistry Research, 8(1-2), 35-42.