A series of 6-alkyl-3β-benzyl-2-(methoxycarbonylmethyl)tropane analogues were synthesized and evaluated as cocaine binding-site ligands at the dopamine transporter (DAT). The in vitro inhibition of [3H]dopamine and the DAT binding affinity (K(i), [3H]WIN 35,428) were measured in rat caudate putamen tissue. Generally, substitution at the 6-position was found to reduce ligand potency.
|Original language||English (US)|
|Number of pages||8|
|Journal||Medicinal Chemistry Research|
|State||Published - Jan 1 1998|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Organic Chemistry