Abstract
A series of 6-alkyl-3β-benzyl-2-(methoxycarbonylmethyl)tropane analogues were synthesized and evaluated as cocaine binding-site ligands at the dopamine transporter (DAT). The in vitro inhibition of [3H]dopamine and the DAT binding affinity (K(i), [3H]WIN 35,428) were measured in rat caudate putamen tissue. Generally, substitution at the 6-position was found to reduce ligand potency.
Original language | English (US) |
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Pages (from-to) | 35-42 |
Number of pages | 8 |
Journal | Medicinal Chemistry Research |
Volume | 8 |
Issue number | 1-2 |
State | Published - Jan 1 1998 |
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Organic Chemistry