TY - JOUR
T1 - AUSWIRKUNGEN DER LUFTVERSCHMUTZUNG AUF DIE LUNGENFUNKTION
AU - Perruchoud, A. P.
AU - Phipps, R. J.
AU - Sielczak, M.
AU - Abraham, W. M.
PY - 1985/12/1
Y1 - 1985/12/1
N2 - The adverse respiratory health effects of air pollution are discussed. Furthermore, the longterm effect of ozone on pulmonary resistance (R(L)), dynamic compliance (C(dyn)), functional residual capacity (FRC), tracheal mucus velocity (TMV) and ciliary beat frequency (CBF) are analyzed. Ozone produces a significant impairment of mucociliary function (10,9 ± 1,0 before, 7,1 ± 1,0 after O3; p<.05), which is maintained even after the cessation of exposure (6,9 ± 1,2; p <.05). These changes in mucus transport are not associated with primary defect in ciliary motility or changes in lung mechanics. Thus, it is likely that the pathophysiologic changes are mostly occurring in the mucus secreting structures and this model is one of simple, non-obstructive bronchitis.
AB - The adverse respiratory health effects of air pollution are discussed. Furthermore, the longterm effect of ozone on pulmonary resistance (R(L)), dynamic compliance (C(dyn)), functional residual capacity (FRC), tracheal mucus velocity (TMV) and ciliary beat frequency (CBF) are analyzed. Ozone produces a significant impairment of mucociliary function (10,9 ± 1,0 before, 7,1 ± 1,0 after O3; p<.05), which is maintained even after the cessation of exposure (6,9 ± 1,2; p <.05). These changes in mucus transport are not associated with primary defect in ciliary motility or changes in lung mechanics. Thus, it is likely that the pathophysiologic changes are mostly occurring in the mucus secreting structures and this model is one of simple, non-obstructive bronchitis.
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M3 - Article
C2 - 4012657
AN - SCOPUS:0022255116
VL - 42
SP - 126
EP - 131
JO - Therapeutische Umschau. Revue therapeutique
JF - Therapeutische Umschau. Revue therapeutique
SN - 0040-5930
IS - 5
ER -