The effects of acute antipsychotic drug administration on the neurotensin system of the developing rat brain

Becky Kinkead, Michael J. Owens, Charles B. Nemeroff

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The effects of antipsychotic drugs on the neurotensin (NT) system have been well characterized in adult male animals. There is considerable evidence that the NT system undergoes distinct age-related changes during development of the rat brain. This observation in conjunction with antipsychotic pharmacotherapy in children and breast feeding women led us to characterize the effects of antipsychotic drug administration in neonatal rats. The effects of a single subcutaneous injection of haloperidol (2.0 mg/kg) on the developing NT system were determined between postnatal days 10 and 21. Haloperidol significantly increased NT/neuromedin N (NT/NN) mRNA expression and NT concentrations in the caudate/putamen as early as postnatal day 10. Haloperidol did not increase NT/NN mRNA expression in the nucleus accumbens until postnatal day 15 and did not increase NT concentrations in this brain region until postnatal day 21. These results demonstrate that there is a critical time point in development before which the NT system does not respond to antipsychotic drug administration in the same manner as the mature rat. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalDevelopmental Brain Research
Volume124
Issue number1-2
DOIs
StatePublished - Nov 30 2000
Externally publishedYes

Keywords

  • Development
  • Haloperidol
  • Ontogeny
  • Schizophrenia

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

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