The effects of a partially purified fraction of an ant venom in rheumatoid arthritis

Roy D Altman, D. R. Schultz, B. Collins-Yudiskas, J. Aldrich, P. I. Arnold, H. E. Brown

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A partially purified extract of an ant venom from the South American tree ant Pseudomyrmex sp. was tested in a double-blind, controlled study of patients with rheumatoid arthritis. Venom treated patients demonstrated an improvement in global efficacy and a decrease in the number of tender/painful joints and swollen joints. Swollen joint index improved in 60% of venom treated patients. Other parameters did not demonstrate significant change. Reduction of joint swelling was followed by symptomatic improvement that was sometimes delayed by weeks. Reactions were limited to erythema at the injection site (all patients), local pruritis (two-thirds of the patients), and fever with malaise (one-third of the patients). Further study of this venom in rheumatoid arthritis appears warranted in view of its apparent favorable efficacy-to-toxicity ratio.

Original languageEnglish
Pages (from-to)277-284
Number of pages8
JournalArthritis and Rheumatism
Volume27
Issue number3
DOIs
StatePublished - May 17 1984

Fingerprint

Ant Venoms
Rheumatoid Arthritis
Venoms
Joints
Ants
Erythema
Pruritus
Double-Blind Method
Fever
Injections

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Altman, R. D., Schultz, D. R., Collins-Yudiskas, B., Aldrich, J., Arnold, P. I., & Brown, H. E. (1984). The effects of a partially purified fraction of an ant venom in rheumatoid arthritis. Arthritis and Rheumatism, 27(3), 277-284. https://doi.org/10.1002/art.1780270305

The effects of a partially purified fraction of an ant venom in rheumatoid arthritis. / Altman, Roy D; Schultz, D. R.; Collins-Yudiskas, B.; Aldrich, J.; Arnold, P. I.; Brown, H. E.

In: Arthritis and Rheumatism, Vol. 27, No. 3, 17.05.1984, p. 277-284.

Research output: Contribution to journalArticle

Altman, RD, Schultz, DR, Collins-Yudiskas, B, Aldrich, J, Arnold, PI & Brown, HE 1984, 'The effects of a partially purified fraction of an ant venom in rheumatoid arthritis', Arthritis and Rheumatism, vol. 27, no. 3, pp. 277-284. https://doi.org/10.1002/art.1780270305
Altman RD, Schultz DR, Collins-Yudiskas B, Aldrich J, Arnold PI, Brown HE. The effects of a partially purified fraction of an ant venom in rheumatoid arthritis. Arthritis and Rheumatism. 1984 May 17;27(3):277-284. https://doi.org/10.1002/art.1780270305
Altman, Roy D ; Schultz, D. R. ; Collins-Yudiskas, B. ; Aldrich, J. ; Arnold, P. I. ; Brown, H. E. / The effects of a partially purified fraction of an ant venom in rheumatoid arthritis. In: Arthritis and Rheumatism. 1984 ; Vol. 27, No. 3. pp. 277-284.
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