The effects of β-(TYR9)melanotropin-(9-18) and H-PHE-ILE-TYR-HIS-SER-TYR-LYS-OH on the analgesic action of morphine

G. Telegdy, L. Vécsei, A. V. Schally, D. H. Coy

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

β-(Tyr9)melanotropin-(9-18), which itself has no analgesic action, as measured by the tail-flick and hot-plate methods, decreased morphine-induced analgesia following intracerebroventricular injection. H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH heptapeptide, which has weak CRF-like activity, had no action on analgesia and was not able to modify morphine-induced analgesia. Compared with ACTH1-24, which in a subcutaneous dose of 100 μg/rat decreased morphine-induced analgesia, the same dose of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH was ineffective.

Original languageEnglish (US)
Pages (from-to)131-134
Number of pages4
JournalNeuropharmacology
Volume22
Issue number1
DOIs
StatePublished - Jan 1983
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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