The effect of tetanic and post tetanic potentiation on facilitation of transmitter release at the frog neuromuscular junction

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Abstract

End plate potentials (e.p.p.s) were recorded from frog neuromuscular junctions blocked with high Mg and/or low Ca. Estimates of f(t), the facilitation contributed by each impulse, were obtained during and following repetitive stimulation from the incremental change in e.p.p. amplitudes following step changes in the stimulation rate during the conditioning and testing trains. Estimates of f(t) increased during the conditioning stimulation and returned to control in the posttetanic period. This increase in f(t) was proportional to the magnitude of tetanic or posttetanic potentiation (PTP) present. PTP was present immediately following the conditioning train. However, if depression occurred during the conditioning train, PTP developed after a delay. It is suggested that facilitation and potentiation represent increases in two independent factors which act jointly to increase the probability of transmitter release.

Original languageEnglish
Pages (from-to)353-371
Number of pages19
JournalJournal of Physiology
Volume234
Issue number2
StatePublished - Dec 1 1973
Externally publishedYes

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Neuromuscular Junction
Excitatory Postsynaptic Potentials
Anura

ASJC Scopus subject areas

  • Physiology

Cite this

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title = "The effect of tetanic and post tetanic potentiation on facilitation of transmitter release at the frog neuromuscular junction",
abstract = "End plate potentials (e.p.p.s) were recorded from frog neuromuscular junctions blocked with high Mg and/or low Ca. Estimates of f(t), the facilitation contributed by each impulse, were obtained during and following repetitive stimulation from the incremental change in e.p.p. amplitudes following step changes in the stimulation rate during the conditioning and testing trains. Estimates of f(t) increased during the conditioning stimulation and returned to control in the posttetanic period. This increase in f(t) was proportional to the magnitude of tetanic or posttetanic potentiation (PTP) present. PTP was present immediately following the conditioning train. However, if depression occurred during the conditioning train, PTP developed after a delay. It is suggested that facilitation and potentiation represent increases in two independent factors which act jointly to increase the probability of transmitter release.",
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