The effect of sublethal X-irradiation on erythropoiesis in the mouse

Luther W. Brady, Arnold M. Markoe, Susan Ruggieri, Isadore Brodsky

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


BALC/c female mice were exposed to 300 R of total body X-irradiation following which erythropoiesis was studied for the next 8 weeks. The data indicate that the initial effects of radiation injury on erythropoiesis is marked depression of both splenic and marrow erynthropoiesis and the development of ineffective release of maturing RBCs from these organs, as demonstrated by marked decreases in organ radioiron uptake and in radioiron reappearance in RBCs, respectively. The data suggest a complex interrelationship between splenic and marrow erythropoiesis following erythropoietic perturbation. We conclude that the mouse spleen may function in a booster capacity to marrow erythropoiesis in the attainment and maintenance of a new steady-state condition.

Original languageEnglish (US)
Pages (from-to)471-479
Number of pages9
JournalInternational Journal of Radiation Oncology, Biology, Physics
Issue number5-6
StatePublished - 1976
Externally publishedYes


  • Marrow erythropoiesis
  • Sublethal X-irradiation
  • Total body irradiation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation


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