The effect of sublethal X-irradiation on erythropoiesis in the mouse

Luther W. Brady; Arnold M. Markoe; Susan Ruggieri; Isadore Brodsky

doi:10.1016/0360-3016(76)90013-4

The effect of sublethal X-irradiation on erythropoiesis in the mouse

Luther W. Brady, Arnold M. Markoe, Susan Ruggieri, Isadore Brodsky

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

BALC/c female mice were exposed to 300 R of total body X-irradiation following which erythropoiesis was studied for the next 8 weeks. The data indicate that the initial effects of radiation injury on erythropoiesis is marked depression of both splenic and marrow erynthropoiesis and the development of ineffective release of maturing RBCs from these organs, as demonstrated by marked decreases in organ radioiron uptake and in radioiron reappearance in RBCs, respectively. The data suggest a complex interrelationship between splenic and marrow erythropoiesis following erythropoietic perturbation. We conclude that the mouse spleen may function in a booster capacity to marrow erythropoiesis in the attainment and maintenance of a new steady-state condition.

Original language	English (US)
Pages (from-to)	471-479
Number of pages	9
Journal	International Journal of Radiation Oncology, Biology, Physics
Volume	1
Issue number	5-6
DOIs	https://doi.org/10.1016/0360-3016(76)90013-4
State	Published - 1976
Externally published	Yes

Keywords

Marrow erythropoiesis
Sublethal X-irradiation
Total body irradiation

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Radiation

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@article{908b8d2dd35446d887fb63105bef8e66,

title = "The effect of sublethal X-irradiation on erythropoiesis in the mouse",

abstract = "BALC/c female mice were exposed to 300 R of total body X-irradiation following which erythropoiesis was studied for the next 8 weeks. The data indicate that the initial effects of radiation injury on erythropoiesis is marked depression of both splenic and marrow erynthropoiesis and the development of ineffective release of maturing RBCs from these organs, as demonstrated by marked decreases in organ radioiron uptake and in radioiron reappearance in RBCs, respectively. The data suggest a complex interrelationship between splenic and marrow erythropoiesis following erythropoietic perturbation. We conclude that the mouse spleen may function in a booster capacity to marrow erythropoiesis in the attainment and maintenance of a new steady-state condition.",

keywords = "Marrow erythropoiesis, Sublethal X-irradiation, Total body irradiation",

author = "Brady, {Luther W.} and Markoe, {Arnold M.} and Susan Ruggieri and Isadore Brodsky",

note = "Funding Information: National Cancer Institute, by PHS Research Grant No. l-RlO-CA12252 from the National Cancer Institute, by PHS Research Grant No. 5-RlO-CA12478 from the National Cancer Institute, and by PHS Center Grant No. l-POl-CA14043-OlAl. Funding Information: ?Department of Radiation Therapy and Nuclear Medicine. iDepartment of Medicine. Ack~towledgements-This paper was supported by PHS Training Grant No. TOl-CA05185 from the",

year = "1976",

doi = "10.1016/0360-3016(76)90013-4",

language = "English (US)",

volume = "1",

pages = "471--479",

journal = "International Journal of Radiation Oncology Biology Physics",

issn = "0360-3016",

publisher = "Elsevier Inc.",

number = "5-6",

}

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T1 - The effect of sublethal X-irradiation on erythropoiesis in the mouse

AU - Brady, Luther W.

AU - Markoe, Arnold M.

AU - Ruggieri, Susan

AU - Brodsky, Isadore

N1 - Funding Information: National Cancer Institute, by PHS Research Grant No. l-RlO-CA12252 from the National Cancer Institute, by PHS Research Grant No. 5-RlO-CA12478 from the National Cancer Institute, and by PHS Center Grant No. l-POl-CA14043-OlAl. Funding Information: ?Department of Radiation Therapy and Nuclear Medicine. iDepartment of Medicine. Ack~towledgements-This paper was supported by PHS Training Grant No. TOl-CA05185 from the

PY - 1976

Y1 - 1976

N2 - BALC/c female mice were exposed to 300 R of total body X-irradiation following which erythropoiesis was studied for the next 8 weeks. The data indicate that the initial effects of radiation injury on erythropoiesis is marked depression of both splenic and marrow erynthropoiesis and the development of ineffective release of maturing RBCs from these organs, as demonstrated by marked decreases in organ radioiron uptake and in radioiron reappearance in RBCs, respectively. The data suggest a complex interrelationship between splenic and marrow erythropoiesis following erythropoietic perturbation. We conclude that the mouse spleen may function in a booster capacity to marrow erythropoiesis in the attainment and maintenance of a new steady-state condition.

AB - BALC/c female mice were exposed to 300 R of total body X-irradiation following which erythropoiesis was studied for the next 8 weeks. The data indicate that the initial effects of radiation injury on erythropoiesis is marked depression of both splenic and marrow erynthropoiesis and the development of ineffective release of maturing RBCs from these organs, as demonstrated by marked decreases in organ radioiron uptake and in radioiron reappearance in RBCs, respectively. The data suggest a complex interrelationship between splenic and marrow erythropoiesis following erythropoietic perturbation. We conclude that the mouse spleen may function in a booster capacity to marrow erythropoiesis in the attainment and maintenance of a new steady-state condition.

KW - Marrow erythropoiesis

KW - Sublethal X-irradiation

KW - Total body irradiation

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