Abstract
BALC/c female mice were exposed to 300 R of total body X-irradiation following which erythropoiesis was studied for the next 8 weeks. The data indicate that the initial effects of radiation injury on erythropoiesis is marked depression of both splenic and marrow erynthropoiesis and the development of ineffective release of maturing RBCs from these organs, as demonstrated by marked decreases in organ radioiron uptake and in radioiron reappearance in RBCs, respectively. The data suggest a complex interrelationship between splenic and marrow erythropoiesis following erythropoietic perturbation. We conclude that the mouse spleen may function in a booster capacity to marrow erythropoiesis in the attainment and maintenance of a new steady-state condition.
| Original language | English |
|---|---|
| Pages (from-to) | 471-479 |
| Number of pages | 9 |
| Journal | International journal of radiation oncology, biology, physics |
| Volume | 1 |
| Issue number | 5-6 |
| DOIs | |
| State | Published - Jan 1 1976 |
| Externally published | Yes |
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Keywords
- Marrow erythropoiesis
- Sublethal X-irradiation
- Total body irradiation
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Radiation
Cite this
The effect of sublethal X-irradiation on erythropoiesis in the mouse. / Brady, Luther W.; Markoe, Arnold; Ruggieri, Susan; Brodsky, Isadore.
In: International journal of radiation oncology, biology, physics, Vol. 1, No. 5-6, 01.01.1976, p. 471-479.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of sublethal X-irradiation on erythropoiesis in the mouse
AU - Brady, Luther W.
AU - Markoe, Arnold
AU - Ruggieri, Susan
AU - Brodsky, Isadore
PY - 1976/1/1
Y1 - 1976/1/1
N2 - BALC/c female mice were exposed to 300 R of total body X-irradiation following which erythropoiesis was studied for the next 8 weeks. The data indicate that the initial effects of radiation injury on erythropoiesis is marked depression of both splenic and marrow erynthropoiesis and the development of ineffective release of maturing RBCs from these organs, as demonstrated by marked decreases in organ radioiron uptake and in radioiron reappearance in RBCs, respectively. The data suggest a complex interrelationship between splenic and marrow erythropoiesis following erythropoietic perturbation. We conclude that the mouse spleen may function in a booster capacity to marrow erythropoiesis in the attainment and maintenance of a new steady-state condition.
AB - BALC/c female mice were exposed to 300 R of total body X-irradiation following which erythropoiesis was studied for the next 8 weeks. The data indicate that the initial effects of radiation injury on erythropoiesis is marked depression of both splenic and marrow erynthropoiesis and the development of ineffective release of maturing RBCs from these organs, as demonstrated by marked decreases in organ radioiron uptake and in radioiron reappearance in RBCs, respectively. The data suggest a complex interrelationship between splenic and marrow erythropoiesis following erythropoietic perturbation. We conclude that the mouse spleen may function in a booster capacity to marrow erythropoiesis in the attainment and maintenance of a new steady-state condition.
KW - Marrow erythropoiesis
KW - Sublethal X-irradiation
KW - Total body irradiation
UR - http://www.scopus.com/inward/record.url?scp=0017182841&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017182841&partnerID=8YFLogxK
U2 - 10.1016/0360-3016(76)90013-4
DO - 10.1016/0360-3016(76)90013-4
M3 - Article
C2 - 972108
AN - SCOPUS:0017182841
VL - 1
SP - 471
EP - 479
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
SN - 0360-3016
IS - 5-6
ER -