The effect of serum ionized calcium elevation on somatostatin inhibition of glucose-induced insulin release in humans.

B. L. Wajchenberg, F. P. Cesar, C. E. Leme, H. B. Silva, A. C. Lerario, D. H. Coy, Andrew V Schally

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of somatostatin on the insulin response to an acute intravenous glucose load was studied in five normal subjects before and after induction hypercalcaemia. In the normocalcaemic state, the insulin response to glucose was depressed by somatostatin. In the hypercalcaemic state, insulin responses to glucose in the presence of somatostatin, were partially restored and appeared to be related to the level of increment of serum ionized calcium. It is concluded that, in the human being, hypercalcaemia and somatostatin have opposite actions on glucose-stimulated insulin secretion.

Original languageEnglish
Pages (from-to)515-521
Number of pages7
JournalClinical Endocrinology
Volume9
Issue number6
StatePublished - Dec 1 1978
Externally publishedYes

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Somatostatin
Insulin
Calcium
Glucose
Hypercalcemia
Serum

ASJC Scopus subject areas

  • Endocrinology

Cite this

Wajchenberg, B. L., Cesar, F. P., Leme, C. E., Silva, H. B., Lerario, A. C., Coy, D. H., & Schally, A. V. (1978). The effect of serum ionized calcium elevation on somatostatin inhibition of glucose-induced insulin release in humans. Clinical Endocrinology, 9(6), 515-521.

The effect of serum ionized calcium elevation on somatostatin inhibition of glucose-induced insulin release in humans. / Wajchenberg, B. L.; Cesar, F. P.; Leme, C. E.; Silva, H. B.; Lerario, A. C.; Coy, D. H.; Schally, Andrew V.

In: Clinical Endocrinology, Vol. 9, No. 6, 01.12.1978, p. 515-521.

Research output: Contribution to journalArticle

Wajchenberg, BL, Cesar, FP, Leme, CE, Silva, HB, Lerario, AC, Coy, DH & Schally, AV 1978, 'The effect of serum ionized calcium elevation on somatostatin inhibition of glucose-induced insulin release in humans.', Clinical Endocrinology, vol. 9, no. 6, pp. 515-521.
Wajchenberg BL, Cesar FP, Leme CE, Silva HB, Lerario AC, Coy DH et al. The effect of serum ionized calcium elevation on somatostatin inhibition of glucose-induced insulin release in humans. Clinical Endocrinology. 1978 Dec 1;9(6):515-521.
Wajchenberg, B. L. ; Cesar, F. P. ; Leme, C. E. ; Silva, H. B. ; Lerario, A. C. ; Coy, D. H. ; Schally, Andrew V. / The effect of serum ionized calcium elevation on somatostatin inhibition of glucose-induced insulin release in humans. In: Clinical Endocrinology. 1978 ; Vol. 9, No. 6. pp. 515-521.
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