The effect of repetitive stimulation on facilitation of transmitter release at the frog neuromuscular junction

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

End plate potentials (e.p.p.s) were recorded from frog neuromuscular junctions blocked with high Mg and/or low Ca to characterize the processes underlying increased transmitter release during repetitive stimulation. There was a progressive increase in the amplitude of successive e.p.p.s during repetitive stimulation. Increasing the frequency or duration of stimulation increased this facilitation of e.p.p. amplitudes. Facilitation is defined as the fractional increase in amplitude of a test e.p.p. over a control.

Original languageEnglish (US)
Pages (from-to)327-352
Number of pages26
JournalThe Journal of Physiology
Volume234
Issue number2
DOIs
StatePublished - Oct 1 1973

ASJC Scopus subject areas

  • Physiology

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