The effect of prednisone on pancreatic islet autografts in dogs

Yijun Zeng, Camillo Ricordi, Javier Lendoire, Patricia B. Carroll, Rodolfo Alejandro, Debora R. Bereiter, Andreas Tzakis, Thomas E. Starzl

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Prednisone was shown to induce hyperglycemia in dogs submitted to total pancreatectomy and pancreatic islet autotransplantation. The hyperglycemia caused by a 10-day course of prednisone, 1 mg/kg/day, starting on the day of operation was reversible within 1 week after steroid discontinuance. Three weeks after prednisone was stopped, there was no detectable adverse effect on glucose homeostasis as judged by fasting blood sugar levels and intravenous glucose tolerance test results. Four months after transplantation, glucose disappearance was delayed in animals previously treated with the prednisone compared with those previously treated with prednisone plus insulin or control animals. This was accompanied by lower insulin values on intravenous glucose tolerance testing and suggests a long-term subtle effect on islet function. The mechanism of the steroid effect is not known. However, this model could be used to test the diabetogenicity of other immunosuppressive agents including cyclosporine, FK 506, and azathioprine.

Original languageEnglish
Pages (from-to)98-102
Number of pages5
JournalSurgery
Volume113
Issue number1
StatePublished - Jan 1 1993

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Autografts
Prednisone
Islets of Langerhans
Dogs
Glucose Tolerance Test
Hyperglycemia
Steroids
Insulin
Glucose
Pancreatectomy
Autologous Transplantation
Azathioprine
Tacrolimus
Immunosuppressive Agents
Cyclosporine
Blood Glucose
Fasting
Homeostasis
Transplantation

ASJC Scopus subject areas

  • Surgery

Cite this

Zeng, Y., Ricordi, C., Lendoire, J., Carroll, P. B., Alejandro, R., Bereiter, D. R., ... Starzl, T. E. (1993). The effect of prednisone on pancreatic islet autografts in dogs. Surgery, 113(1), 98-102.

The effect of prednisone on pancreatic islet autografts in dogs. / Zeng, Yijun; Ricordi, Camillo; Lendoire, Javier; Carroll, Patricia B.; Alejandro, Rodolfo; Bereiter, Debora R.; Tzakis, Andreas; Starzl, Thomas E.

In: Surgery, Vol. 113, No. 1, 01.01.1993, p. 98-102.

Research output: Contribution to journalArticle

Zeng, Y, Ricordi, C, Lendoire, J, Carroll, PB, Alejandro, R, Bereiter, DR, Tzakis, A & Starzl, TE 1993, 'The effect of prednisone on pancreatic islet autografts in dogs', Surgery, vol. 113, no. 1, pp. 98-102.
Zeng Y, Ricordi C, Lendoire J, Carroll PB, Alejandro R, Bereiter DR et al. The effect of prednisone on pancreatic islet autografts in dogs. Surgery. 1993 Jan 1;113(1):98-102.
Zeng, Yijun ; Ricordi, Camillo ; Lendoire, Javier ; Carroll, Patricia B. ; Alejandro, Rodolfo ; Bereiter, Debora R. ; Tzakis, Andreas ; Starzl, Thomas E. / The effect of prednisone on pancreatic islet autografts in dogs. In: Surgery. 1993 ; Vol. 113, No. 1. pp. 98-102.
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