Abstract
Prednisone was shown to induce hyperglycemia in dogs submitted to total pancreatectomy and pancreatic islet autotransplantation. The hyperglycemia caused by a 10-day course of prednisone, 1 mg/kg/day, starting on the day of operation was reversible within 1 week after steroid discontinuance. Three weeks after prednisone was stopped, there was no detectable adverse effect on glucose homeostasis as judged by fasting blood sugar levels and intravenous glucose tolerance test results. Four months after transplantation, glucose disappearance was delayed in animals previously treated with the prednisone compared with those previously treated with prednisone plus insulin or control animals. This was accompanied by lower insulin values on intravenous glucose tolerance testing and suggests a long-term subtle effect on islet function. The mechanism of the steroid effect is not known. However, this model could be used to test the diabetogenicity of other immunosuppressive agents including cyclosporine, FK 506, and azathioprine.
| Original language | English |
|---|---|
| Pages (from-to) | 98-102 |
| Number of pages | 5 |
| Journal | Surgery |
| Volume | 113 |
| Issue number | 1 |
| State | Published - Jan 1 1993 |
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ASJC Scopus subject areas
- Surgery
Cite this
The effect of prednisone on pancreatic islet autografts in dogs. / Zeng, Yijun; Ricordi, Camillo; Lendoire, Javier; Carroll, Patricia B.; Alejandro, Rodolfo; Bereiter, Debora R.; Tzakis, Andreas; Starzl, Thomas E.
In: Surgery, Vol. 113, No. 1, 01.01.1993, p. 98-102.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The effect of prednisone on pancreatic islet autografts in dogs
AU - Zeng, Yijun
AU - Ricordi, Camillo
AU - Lendoire, Javier
AU - Carroll, Patricia B.
AU - Alejandro, Rodolfo
AU - Bereiter, Debora R.
AU - Tzakis, Andreas
AU - Starzl, Thomas E.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Prednisone was shown to induce hyperglycemia in dogs submitted to total pancreatectomy and pancreatic islet autotransplantation. The hyperglycemia caused by a 10-day course of prednisone, 1 mg/kg/day, starting on the day of operation was reversible within 1 week after steroid discontinuance. Three weeks after prednisone was stopped, there was no detectable adverse effect on glucose homeostasis as judged by fasting blood sugar levels and intravenous glucose tolerance test results. Four months after transplantation, glucose disappearance was delayed in animals previously treated with the prednisone compared with those previously treated with prednisone plus insulin or control animals. This was accompanied by lower insulin values on intravenous glucose tolerance testing and suggests a long-term subtle effect on islet function. The mechanism of the steroid effect is not known. However, this model could be used to test the diabetogenicity of other immunosuppressive agents including cyclosporine, FK 506, and azathioprine.
AB - Prednisone was shown to induce hyperglycemia in dogs submitted to total pancreatectomy and pancreatic islet autotransplantation. The hyperglycemia caused by a 10-day course of prednisone, 1 mg/kg/day, starting on the day of operation was reversible within 1 week after steroid discontinuance. Three weeks after prednisone was stopped, there was no detectable adverse effect on glucose homeostasis as judged by fasting blood sugar levels and intravenous glucose tolerance test results. Four months after transplantation, glucose disappearance was delayed in animals previously treated with the prednisone compared with those previously treated with prednisone plus insulin or control animals. This was accompanied by lower insulin values on intravenous glucose tolerance testing and suggests a long-term subtle effect on islet function. The mechanism of the steroid effect is not known. However, this model could be used to test the diabetogenicity of other immunosuppressive agents including cyclosporine, FK 506, and azathioprine.
UR - http://www.scopus.com/inward/record.url?scp=0027399825&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027399825&partnerID=8YFLogxK
M3 - Article
C2 - 8417496
AN - SCOPUS:0027399825
VL - 113
SP - 98
EP - 102
JO - Surgery (United States)
JF - Surgery (United States)
SN - 0039-6060
IS - 1
ER -