The effect of perioperative blood transfusion on survival in head and neck cancer

D. E. Schuller, C. Scott, K. M. Wilson, R. Freer, M. Al-Sarraf, J. Jacobs, K. Ahmad, Roy R Casiano, G. Laramore

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

This Head and Neck Intergroup analysis was undertaken to evaluate further previously reported observations linking blood transfusions, which were given to patients with head and neck cancer, to a worse prognosis. This study population represents those patients registered to the Head and Neck Intergroup Trial 0034 for previously untreated resectable squamous cell carcinoma. Additional transfusion data were obtained by one of us (D.E.S.) on 217 patients and added to the Head and Neck Intergroup data set, providing an opportunity for assessing the impact of survival by other variables. The study group was separated using 13 variables. Analysis demonstrated that transfusion did not significantly decrease the locoregional control (P=.60). Multivariate analysis indicated that T stage (P=.015), N stage (P=.004), treatment received (P=.004), and Karnofsky Performance Scale (P=.031) were the only factors that did significantly influence survival. This multivariate analysis controlling for these variables demonstrated no significant effect on survival for those patients receiving transfusion during surgery (P=.55) or after surgery (P=.39). This study of 217 patients, controlled for other variables, does not demonstrate any significant negative relation between blood transfusions and either locoregional control or survival.

Original languageEnglish
Pages (from-to)711-716
Number of pages6
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume120
Issue number7
StatePublished - Jan 1 1994
Externally publishedYes

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Head and Neck Neoplasms
Blood Transfusion
Survival
Neck
Head
Multivariate Analysis
Karnofsky Performance Status
Squamous Cell Carcinoma
Population
Therapeutics

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Schuller, D. E., Scott, C., Wilson, K. M., Freer, R., Al-Sarraf, M., Jacobs, J., ... Laramore, G. (1994). The effect of perioperative blood transfusion on survival in head and neck cancer. Archives of Otolaryngology - Head and Neck Surgery, 120(7), 711-716.

The effect of perioperative blood transfusion on survival in head and neck cancer. / Schuller, D. E.; Scott, C.; Wilson, K. M.; Freer, R.; Al-Sarraf, M.; Jacobs, J.; Ahmad, K.; Casiano, Roy R; Laramore, G.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 120, No. 7, 01.01.1994, p. 711-716.

Research output: Contribution to journalArticle

Schuller, DE, Scott, C, Wilson, KM, Freer, R, Al-Sarraf, M, Jacobs, J, Ahmad, K, Casiano, RR & Laramore, G 1994, 'The effect of perioperative blood transfusion on survival in head and neck cancer', Archives of Otolaryngology - Head and Neck Surgery, vol. 120, no. 7, pp. 711-716.
Schuller DE, Scott C, Wilson KM, Freer R, Al-Sarraf M, Jacobs J et al. The effect of perioperative blood transfusion on survival in head and neck cancer. Archives of Otolaryngology - Head and Neck Surgery. 1994 Jan 1;120(7):711-716.
Schuller, D. E. ; Scott, C. ; Wilson, K. M. ; Freer, R. ; Al-Sarraf, M. ; Jacobs, J. ; Ahmad, K. ; Casiano, Roy R ; Laramore, G. / The effect of perioperative blood transfusion on survival in head and neck cancer. In: Archives of Otolaryngology - Head and Neck Surgery. 1994 ; Vol. 120, No. 7. pp. 711-716.
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