The effect of neurotensin on food consumption in the rat

Daniel Luttinger, Richard A. King, David Sheppard, John Strupp, Charles B. Nemeroff, Arthur J. Prange

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

The effects of neurotensin on feeding behavior were studied in rats. Intracerebroventricular administration of neurotensin (3.3-30 μg) produced a dose-related decrease in food intake in 24 h food deprived rats. Acute intracerebroventricular injection of neurotensin (30 μg) shortly after the ingestion of a novel flavor did not produce a flavor aversion during testing 48 h later, suggesting that reduction of food intake by low doses of centrally administered neurotensin is not related to a conditioned taste aversion. Intracerebroventricularly administered thyrotropin-releasing hormone (2.2 μg) also inhibited food intake and appeared to attenuate slightly the inhibition of food intake induced by 10 μg neurotensin.

Original languageEnglish (US)
Pages (from-to)499-503
Number of pages5
JournalEuropean Journal of Pharmacology
Volume81
Issue number3
DOIs
StatePublished - Jul 16 1982
Externally publishedYes

Keywords

  • Feeding
  • Neuropeptide
  • Neurotensin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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