The effects of neurotensin on feeding behavior were studied in rats. Intracerebroventricular administration of neurotensin (3.3-30 μg) produced a dose-related decrease in food intake in 24 h food deprived rats. Acute intracerebroventricular injection of neurotensin (30 μg) shortly after the ingestion of a novel flavor did not produce a flavor aversion during testing 48 h later, suggesting that reduction of food intake by low doses of centrally administered neurotensin is not related to a conditioned taste aversion. Intracerebroventricularly administered thyrotropin-releasing hormone (2.2 μg) also inhibited food intake and appeared to attenuate slightly the inhibition of food intake induced by 10 μg neurotensin.
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience