The effect of neurotensin on food consumption in the rat

Daniel Luttinger, Richard A. King, David Sheppard, John Strupp, Charles Nemeroff, Arthur J. Prange

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

The effects of neurotensin on feeding behavior were studied in rats. Intracerebroventricular administration of neurotensin (3.3-30 μg) produced a dose-related decrease in food intake in 24 h food deprived rats. Acute intracerebroventricular injection of neurotensin (30 μg) shortly after the ingestion of a novel flavor did not produce a flavor aversion during testing 48 h later, suggesting that reduction of food intake by low doses of centrally administered neurotensin is not related to a conditioned taste aversion. Intracerebroventricularly administered thyrotropin-releasing hormone (2.2 μg) also inhibited food intake and appeared to attenuate slightly the inhibition of food intake induced by 10 μg neurotensin.

Original languageEnglish
Pages (from-to)499-503
Number of pages5
JournalEuropean Journal of Pharmacology
Volume81
Issue number3
DOIs
StatePublished - Jul 16 1982
Externally publishedYes

Fingerprint

Neurotensin
Eating
Food
Thyrotropin-Releasing Hormone
Feeding Behavior
Injections

Keywords

  • Feeding
  • Neuropeptide
  • Neurotensin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Luttinger, D., King, R. A., Sheppard, D., Strupp, J., Nemeroff, C., & Prange, A. J. (1982). The effect of neurotensin on food consumption in the rat. European Journal of Pharmacology, 81(3), 499-503. https://doi.org/10.1016/0014-2999(82)90116-9

The effect of neurotensin on food consumption in the rat. / Luttinger, Daniel; King, Richard A.; Sheppard, David; Strupp, John; Nemeroff, Charles; Prange, Arthur J.

In: European Journal of Pharmacology, Vol. 81, No. 3, 16.07.1982, p. 499-503.

Research output: Contribution to journalArticle

Luttinger, D, King, RA, Sheppard, D, Strupp, J, Nemeroff, C & Prange, AJ 1982, 'The effect of neurotensin on food consumption in the rat', European Journal of Pharmacology, vol. 81, no. 3, pp. 499-503. https://doi.org/10.1016/0014-2999(82)90116-9
Luttinger, Daniel ; King, Richard A. ; Sheppard, David ; Strupp, John ; Nemeroff, Charles ; Prange, Arthur J. / The effect of neurotensin on food consumption in the rat. In: European Journal of Pharmacology. 1982 ; Vol. 81, No. 3. pp. 499-503.
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