The Effect of Neomycin Sulfate on Pancreatic Lipase Activity

Arvey I. Rogers, Paul S. Bachorik

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In separating the various effects of neomycin sulfate which may be exerted in systems designed to measure the activity of lipase, it is apparent that the antibiotic enhances the activity of both porcine and human lipase on an insoluble substrate. Additionally, it has the propensity to unstabilize emulsions. These effects are antagonistic and may account for divergent results previously recorded regarding neomycin-lipase interrelationships. Both the enzyme enchancing and emulsion unstabilizing properties of the antibiotic seem to reside in the presence of its free amino groups.

Original languageEnglish (US)
Pages (from-to)1236-1240
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume127
Issue number4
DOIs
StatePublished - Apr 1968

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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