The effect of moxifloxacin on the normal human cornea

Kendall E. Donaldson, Fabiana B. Marangon, Lauren Schatz, Anna S. Venkatraman, Eduardo C. Alfonso

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Objective: To investigate the effects of moxifloxacin on the cornea of normal human eyes using confocal microscopy and slit-lamp biomicroscopy. Methods: This study enrolled adult volunteers who had a normal baseline ophthalmic examination. The dose regimen, similar to that of patients undergoing cataract extraction, was one drop of moxifloxacin in one eye four times a day for 3 days. The untreated fellow eye served as the control. Subjects had a baseline examination (Visit 1), started moxifloxacin the next day, and were examined 24 h (Visit 2) and 72 h (visit 3) after starting medication. At each visit, visual acuity and adverse effects were recorded, slit-lamp examination with fluorescein was used to measure tear break-up time, and endothelial and epithelial cell counts were determined using confocal microscopy. Results: Fifteen volunteers (mean age 37 ± 7 years) enrolled. No significant difference In visual acuity, tear break-up time, endothelial or epithelial cell counts was noted between the treated and fellow eye. Subjects experienced no significant decrease in visual acuity, tear break-up time, or endothelial cell counts during the 3-day treatment period in either eye. Epithelial cell counts were stable at Visits 1 and 2, and decreased similarly in the treated and control eye at Visit 3. Conclusions: Moxifloxacin was safe for use during the 3-day treatment period. Moxifloxacin causes no significant epithelial or endothelial toxicity, and has no effect on visual acuity or ocular surface integrity in healthy subjects treated using a dosing regimen that simulated prophylactic use following cataract surgery.

Original languageEnglish (US)
Pages (from-to)2073-2078
Number of pages6
JournalCurrent Medical Research and Opinion
Volume22
Issue number10
DOIs
StatePublished - Oct 1 2006

Keywords

  • Confocal microscopy
  • Cornea
  • Moxifloxacin
  • Toxicity

ASJC Scopus subject areas

  • Medicine(all)

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