The effect of metoclopramide on gastric acid secretion and the rate of gastric emptying in normals and duodenal ulcer patients was studied. The author compared the effect of 10, 20 and 40 mg IV of metoclopramide and IV injection of placebo (0.15 N NaCl) on basal acid output (BAO) and augmented histamine acid output (MAO) in 30 normal subjects, 30 duodenal ulcer patients with intact stomach (DU) and 30 duodenal ulcer patients after surgical truncal vagotomy and pyloroplasty (STV); the effect of 10 mg of metoclopramide and placebo on the rate of gastric emptying of an isotonic saline 'test meal' in 10 normal subjects and 10 STV patients; and the effect of 40 mg IV of metoclopramide and placebo on the rate of gastric emptying of an isotonic saline 'test meal', the secretion of acid and the serum gastrin in 12 normal subjects and 10 STV patients. Metoclopramide had no effect on BAO and MAO in normals, DU or STV patients. Metoclopramide compared with placebo increased the rate of gastric emptying (p < 0.001) in both normal subjects and STV patients, but had no effect on acid secretion and serum gastrin. The results indicate that in humans: metoclopramide increases the rate of emptying of both intact and vagotomized stomach; this effect on gastric emptying is not related to the release of gastrin; the mechanism of action is independent of the integrity of the vagus nerves; and metoclopramide has no effect on gastric acid secretion.
|Original language||English (US)|
|Number of pages||7|
|Journal||Acta gastroenterologica Latinoamericana|
|State||Published - Dec 1 1974|
ASJC Scopus subject areas