Abstract
Female Wistar rats were fed a semisynthetic diet containing 0.3% DL-ethionine for 52 weeks and, most of them bearing hepatocellular carcinomas, were switched to a basal diet for one week and then received 80 mg DL-methionine per rat (cir. 25 mg/100 g body wt) by gavage once per day, five times a week, over a period of 13 weeks. Methionine treatment significantly affected progression of hepatic tumors induced by DL-ethionine administration. The frequency of rats with hepatocellular carcinomas in the methionine treated group was significantly lower than that in control groups. It therefore appears that methionine treatment resulted in a remission of the malignant process.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 157-160 |
| Number of pages | 4 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 38 |
| Issue number | 1 |
| State | Published - Jan 1 1982 |
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)
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Brada, Z., Altman, N. H., Hill, M., & Bulba, S. (1982). The effect of methionine on the progression of hepatocellular carcinoma induced by ethionine. Research Communications in Chemical Pathology and Pharmacology, 38(1), 157-160.