The effect of methionine on the progression of hepatocellular carcinoma induced by ethionine

Z. Brada, N. H. Altman, M. Hill, S. Bulba

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Female Wistar rats were fed a semisynthetic diet containing 0.3% DL-ethionine for 52 weeks and, most of them bearing hepatocellular carcinomas, were switched to a basal diet for one week and then received 80 mg DL-methionine per rat (cir. 25 mg/100 g body wt) by gavage once per day, five times a week, over a period of 13 weeks. Methionine treatment significantly affected progression of hepatic tumors induced by DL-ethionine administration. The frequency of rats with hepatocellular carcinomas in the methionine treated group was significantly lower than that in control groups. It therefore appears that methionine treatment resulted in a remission of the malignant process.

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume38
Issue number1
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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