The effect of low-dose remifentanil on responses to the endotracheal tube during emergence from general anesthesia

Marie T. Aouad, Achir A. Al-Alami, Viviane G. Nasr, Fouad G. Souki, Reine A. Zbeidy, Sahar M. Siddik-Sayyid

Research output: Contribution to journalArticle

55 Scopus citations


BACKGROUND:: Emergence from general anesthesia can be associated with coughing, agitation, and hemodynamic disturbances. Remifentanil may attenuate these responses. METHODS:: In a prospective, double-blind, randomized trial, we enrolled 60 adult patients undergoing nasal surgery using remifentanil-based anesthesia. During the emergence phase, the remifentanil group had remifentanil reduced to one tenth of the maintenance rate, whereas the control group had remifentanil discontinued. RESULTS:: Times to awakening and tracheal extubation were similar between the two groups. During emergence, the remifentanil group (infusion rate 0.014 ± 0.011 μg • kg • min) had a significantly lower incidence (40% vs 80%, P = 0.002) and less severe coughing compared with the control group, as well as a lower incidence of nonpurposeful movement (3.3% vs 30%, P = 0.006) and slower heart rates. CONCLUSIONS:: Low-dose remifentanil during emergence did not prolong wake-up but reduced the incidence and severity of coughing from the endotracheal tube.

Original languageEnglish (US)
Pages (from-to)1157-1160
Number of pages4
JournalAnesthesia and analgesia
Issue number4
StatePublished - Apr 2009


ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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