The effect of low-dose remifentanil on responses to the endotracheal tube during emergence from general anesthesia

Marie T. Aouad, Achir A. Al-Alami, Viviane G. Nasr, Fouad Souki, Reine A. Zbeidy, Sahar M. Siddik-Sayyid

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

BACKGROUND:: Emergence from general anesthesia can be associated with coughing, agitation, and hemodynamic disturbances. Remifentanil may attenuate these responses. METHODS:: In a prospective, double-blind, randomized trial, we enrolled 60 adult patients undergoing nasal surgery using remifentanil-based anesthesia. During the emergence phase, the remifentanil group had remifentanil reduced to one tenth of the maintenance rate, whereas the control group had remifentanil discontinued. RESULTS:: Times to awakening and tracheal extubation were similar between the two groups. During emergence, the remifentanil group (infusion rate 0.014 ± 0.011 μg • kg • min) had a significantly lower incidence (40% vs 80%, P = 0.002) and less severe coughing compared with the control group, as well as a lower incidence of nonpurposeful movement (3.3% vs 30%, P = 0.006) and slower heart rates. CONCLUSIONS:: Low-dose remifentanil during emergence did not prolong wake-up but reduced the incidence and severity of coughing from the endotracheal tube.

Original languageEnglish
Pages (from-to)1157-1160
Number of pages4
JournalAnesthesia and Analgesia
Volume108
Issue number4
DOIs
StatePublished - Apr 1 2009
Externally publishedYes

Fingerprint

General Anesthesia
Incidence
Airway Extubation
Nasal Surgical Procedures
Control Groups
remifentanil
Anesthesia
Heart Rate
Hemodynamics
Maintenance

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

The effect of low-dose remifentanil on responses to the endotracheal tube during emergence from general anesthesia. / Aouad, Marie T.; Al-Alami, Achir A.; Nasr, Viviane G.; Souki, Fouad; Zbeidy, Reine A.; Siddik-Sayyid, Sahar M.

In: Anesthesia and Analgesia, Vol. 108, No. 4, 01.04.2009, p. 1157-1160.

Research output: Contribution to journalArticle

Aouad, Marie T. ; Al-Alami, Achir A. ; Nasr, Viviane G. ; Souki, Fouad ; Zbeidy, Reine A. ; Siddik-Sayyid, Sahar M. / The effect of low-dose remifentanil on responses to the endotracheal tube during emergence from general anesthesia. In: Anesthesia and Analgesia. 2009 ; Vol. 108, No. 4. pp. 1157-1160.
@article{c2245c545b3b456e8790662d34eb78cd,
title = "The effect of low-dose remifentanil on responses to the endotracheal tube during emergence from general anesthesia",
abstract = "BACKGROUND:: Emergence from general anesthesia can be associated with coughing, agitation, and hemodynamic disturbances. Remifentanil may attenuate these responses. METHODS:: In a prospective, double-blind, randomized trial, we enrolled 60 adult patients undergoing nasal surgery using remifentanil-based anesthesia. During the emergence phase, the remifentanil group had remifentanil reduced to one tenth of the maintenance rate, whereas the control group had remifentanil discontinued. RESULTS:: Times to awakening and tracheal extubation were similar between the two groups. During emergence, the remifentanil group (infusion rate 0.014 ± 0.011 μg • kg • min) had a significantly lower incidence (40{\%} vs 80{\%}, P = 0.002) and less severe coughing compared with the control group, as well as a lower incidence of nonpurposeful movement (3.3{\%} vs 30{\%}, P = 0.006) and slower heart rates. CONCLUSIONS:: Low-dose remifentanil during emergence did not prolong wake-up but reduced the incidence and severity of coughing from the endotracheal tube.",
author = "Aouad, {Marie T.} and Al-Alami, {Achir A.} and Nasr, {Viviane G.} and Fouad Souki and Zbeidy, {Reine A.} and Siddik-Sayyid, {Sahar M.}",
year = "2009",
month = "4",
day = "1",
doi = "10.1213/ane.0b013e31819b03d8",
language = "English",
volume = "108",
pages = "1157--1160",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - The effect of low-dose remifentanil on responses to the endotracheal tube during emergence from general anesthesia

AU - Aouad, Marie T.

AU - Al-Alami, Achir A.

AU - Nasr, Viviane G.

AU - Souki, Fouad

AU - Zbeidy, Reine A.

AU - Siddik-Sayyid, Sahar M.

PY - 2009/4/1

Y1 - 2009/4/1

N2 - BACKGROUND:: Emergence from general anesthesia can be associated with coughing, agitation, and hemodynamic disturbances. Remifentanil may attenuate these responses. METHODS:: In a prospective, double-blind, randomized trial, we enrolled 60 adult patients undergoing nasal surgery using remifentanil-based anesthesia. During the emergence phase, the remifentanil group had remifentanil reduced to one tenth of the maintenance rate, whereas the control group had remifentanil discontinued. RESULTS:: Times to awakening and tracheal extubation were similar between the two groups. During emergence, the remifentanil group (infusion rate 0.014 ± 0.011 μg • kg • min) had a significantly lower incidence (40% vs 80%, P = 0.002) and less severe coughing compared with the control group, as well as a lower incidence of nonpurposeful movement (3.3% vs 30%, P = 0.006) and slower heart rates. CONCLUSIONS:: Low-dose remifentanil during emergence did not prolong wake-up but reduced the incidence and severity of coughing from the endotracheal tube.

AB - BACKGROUND:: Emergence from general anesthesia can be associated with coughing, agitation, and hemodynamic disturbances. Remifentanil may attenuate these responses. METHODS:: In a prospective, double-blind, randomized trial, we enrolled 60 adult patients undergoing nasal surgery using remifentanil-based anesthesia. During the emergence phase, the remifentanil group had remifentanil reduced to one tenth of the maintenance rate, whereas the control group had remifentanil discontinued. RESULTS:: Times to awakening and tracheal extubation were similar between the two groups. During emergence, the remifentanil group (infusion rate 0.014 ± 0.011 μg • kg • min) had a significantly lower incidence (40% vs 80%, P = 0.002) and less severe coughing compared with the control group, as well as a lower incidence of nonpurposeful movement (3.3% vs 30%, P = 0.006) and slower heart rates. CONCLUSIONS:: Low-dose remifentanil during emergence did not prolong wake-up but reduced the incidence and severity of coughing from the endotracheal tube.

UR - http://www.scopus.com/inward/record.url?scp=63849099519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=63849099519&partnerID=8YFLogxK

U2 - 10.1213/ane.0b013e31819b03d8

DO - 10.1213/ane.0b013e31819b03d8

M3 - Article

C2 - 19299779

AN - SCOPUS:63849099519

VL - 108

SP - 1157

EP - 1160

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 4

ER -