The effect of lipid absorption on the mechanical properties of poly(styrene-block-isobutylene-block-styrene) for use in biomedical applications

Alexandra Damley-Strnad, Mauro Fittipaldi, Brigitte Morales, Landon R Grace

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The decrease in tensile strength and increase in specimen weight due to lipid diffusion in a biocompatible thermoplastic elastomer was studied and quantified. Mechanical and viscoelastic properties of poly(styrene-isobutylene-styrene) (SIBS) block copolymer are critical to determine feasibility of certain load bearing in vivo applications. Moreover, changes of these properties due to the presence of lipids must be well understood for long-term bio implantation. Dumbbell specimens were thermoformed via injection molding and weights were recorded. Lipid uptake in the body was simulated by specimen immersion in palm and castor oils at 25 °C and 37 °C. After only 96 hours of immersion at body temperature (37 °C), dumbbell weight increased by 6% and 0.3% for palm oil and castor oil, respectively. These values correspond to a reduction in ultimate tensile strength of approximately 30% and 10%, respectively. These results restrict the use of this biocompatible polymer in certain critical components due to the high concentration of lipids in vivo. Based on these significant and rapid reductions in tensile strength in the presence of lipids, it is of vital importance to fully understand the bio-durability and lipid uptake characteristics of SIBS for future design and performance prediction of implantable devices. Further, the results highlight the necessity of improving lipid resistance in order to fully exploit the biocompatibility of SIBS.

Original languageEnglish (US)
Title of host publicationProceedings of PPS 2016
Subtitle of host publicationThe 32nd International Conference of the Polymer Processing Society - Conference Papers
PublisherAmerican Institute of Physics Inc.
Volume1914
ISBN (Electronic)9780735416062
DOIs
StatePublished - Dec 14 2017
Event32nd International Conference of the Polymer Processing Society, PPS 2016 - Lyon, France
Duration: Jul 25 2016Jul 29 2016

Other

Other32nd International Conference of the Polymer Processing Society, PPS 2016
CountryFrance
CityLyon
Period7/25/167/29/16

Fingerprint

butenes
styrenes
lipids
polystyrene
mechanical properties
castor oil
tensile strength
oils
submerging
body temperature
performance prediction
injection molding
biocompatibility
elastomers
block copolymers
durability
implantation
polymers
predictions

Keywords

  • Bio-degradation
  • Lipid Absorption
  • SIBS
  • Tensile Strength

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Damley-Strnad, A., Fittipaldi, M., Morales, B., & Grace, L. R. (2017). The effect of lipid absorption on the mechanical properties of poly(styrene-block-isobutylene-block-styrene) for use in biomedical applications. In Proceedings of PPS 2016: The 32nd International Conference of the Polymer Processing Society - Conference Papers (Vol. 1914). [120002] American Institute of Physics Inc.. https://doi.org/10.1063/1.5016760

The effect of lipid absorption on the mechanical properties of poly(styrene-block-isobutylene-block-styrene) for use in biomedical applications. / Damley-Strnad, Alexandra; Fittipaldi, Mauro; Morales, Brigitte; Grace, Landon R.

Proceedings of PPS 2016: The 32nd International Conference of the Polymer Processing Society - Conference Papers. Vol. 1914 American Institute of Physics Inc., 2017. 120002.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Damley-Strnad, A, Fittipaldi, M, Morales, B & Grace, LR 2017, The effect of lipid absorption on the mechanical properties of poly(styrene-block-isobutylene-block-styrene) for use in biomedical applications. in Proceedings of PPS 2016: The 32nd International Conference of the Polymer Processing Society - Conference Papers. vol. 1914, 120002, American Institute of Physics Inc., 32nd International Conference of the Polymer Processing Society, PPS 2016, Lyon, France, 7/25/16. https://doi.org/10.1063/1.5016760
Damley-Strnad A, Fittipaldi M, Morales B, Grace LR. The effect of lipid absorption on the mechanical properties of poly(styrene-block-isobutylene-block-styrene) for use in biomedical applications. In Proceedings of PPS 2016: The 32nd International Conference of the Polymer Processing Society - Conference Papers. Vol. 1914. American Institute of Physics Inc. 2017. 120002 https://doi.org/10.1063/1.5016760
Damley-Strnad, Alexandra ; Fittipaldi, Mauro ; Morales, Brigitte ; Grace, Landon R. / The effect of lipid absorption on the mechanical properties of poly(styrene-block-isobutylene-block-styrene) for use in biomedical applications. Proceedings of PPS 2016: The 32nd International Conference of the Polymer Processing Society - Conference Papers. Vol. 1914 American Institute of Physics Inc., 2017.
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abstract = "The decrease in tensile strength and increase in specimen weight due to lipid diffusion in a biocompatible thermoplastic elastomer was studied and quantified. Mechanical and viscoelastic properties of poly(styrene-isobutylene-styrene) (SIBS) block copolymer are critical to determine feasibility of certain load bearing in vivo applications. Moreover, changes of these properties due to the presence of lipids must be well understood for long-term bio implantation. Dumbbell specimens were thermoformed via injection molding and weights were recorded. Lipid uptake in the body was simulated by specimen immersion in palm and castor oils at 25 °C and 37 °C. After only 96 hours of immersion at body temperature (37 °C), dumbbell weight increased by 6{\%} and 0.3{\%} for palm oil and castor oil, respectively. These values correspond to a reduction in ultimate tensile strength of approximately 30{\%} and 10{\%}, respectively. These results restrict the use of this biocompatible polymer in certain critical components due to the high concentration of lipids in vivo. Based on these significant and rapid reductions in tensile strength in the presence of lipids, it is of vital importance to fully understand the bio-durability and lipid uptake characteristics of SIBS for future design and performance prediction of implantable devices. Further, the results highlight the necessity of improving lipid resistance in order to fully exploit the biocompatibility of SIBS.",
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