The effect of intracisternally administered bombesin on cysteamine-induced duodenal ulcers in rats

Daniel E. Hernandez, Jimmie W. Adcock, Charles Nemeroff, Arthur J. Prange

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Cysteamine (420 mg/kg s.c.) increased gastric acid secretion in rats 3-6 h post-injection; duodenal pH fell from 6.0±0.2 (S.E.M.) at 0 time to 2.2.±0.3 at 12 h. A high (60-80%) incidence of duodenal ulcerations was observed 18 h after cysteamine injection. Intracisternal (i.c.) administration of bombesin (1 μg) significantly inhibited both cysteamine-induced increases in gastric acid secretion and the development of duodenal ulcers. The effect of bombesin was dose-dependent and appears to be relatively specific since i.c. neurotensin (1 or 30 μg) was not cytoprotective. Peripheral cholinergic (muscarinic) blockade with atropine methylbromide (10 mg/kg i.p.) was as effective as i.c. bombesin (1 μg) in inhibiting cysteamine-induced gastric hypersecretion and duodenal ulcers.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalEuropean Journal of Pharmacology
Volume84
Issue number3-4
DOIs
StatePublished - Oct 22 1982
Externally publishedYes

Fingerprint

Cysteamine
Bombesin
Duodenal Ulcer
Gastric Acid
Cholinergic Agents
Neurotensin
Injections
Stomach Ulcer
Incidence

Keywords

  • Bombesin
  • Cysteamine
  • Duodenal ulcers
  • Gastric acid secretion
  • Neuropeptides
  • Neurotensin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

The effect of intracisternally administered bombesin on cysteamine-induced duodenal ulcers in rats. / Hernandez, Daniel E.; Adcock, Jimmie W.; Nemeroff, Charles; Prange, Arthur J.

In: European Journal of Pharmacology, Vol. 84, No. 3-4, 22.10.1982, p. 205-209.

Research output: Contribution to journalArticle

Hernandez, Daniel E. ; Adcock, Jimmie W. ; Nemeroff, Charles ; Prange, Arthur J. / The effect of intracisternally administered bombesin on cysteamine-induced duodenal ulcers in rats. In: European Journal of Pharmacology. 1982 ; Vol. 84, No. 3-4. pp. 205-209.
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