The effect of intracisternally administered bombesin on cysteamine-induced duodenal ulcers in rats

Daniel E. Hernandez, Jimmie W. Adcock, Charles B. Nemeroff, Arthur J. Prange

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Cysteamine (420 mg/kg s.c.) increased gastric acid secretion in rats 3-6 h post-injection; duodenal pH fell from 6.0±0.2 (S.E.M.) at 0 time to 2.2.±0.3 at 12 h. A high (60-80%) incidence of duodenal ulcerations was observed 18 h after cysteamine injection. Intracisternal (i.c.) administration of bombesin (1 μg) significantly inhibited both cysteamine-induced increases in gastric acid secretion and the development of duodenal ulcers. The effect of bombesin was dose-dependent and appears to be relatively specific since i.c. neurotensin (1 or 30 μg) was not cytoprotective. Peripheral cholinergic (muscarinic) blockade with atropine methylbromide (10 mg/kg i.p.) was as effective as i.c. bombesin (1 μg) in inhibiting cysteamine-induced gastric hypersecretion and duodenal ulcers.

Original languageEnglish (US)
Pages (from-to)205-209
Number of pages5
JournalEuropean Journal of Pharmacology
Volume84
Issue number3-4
DOIs
StatePublished - Oct 22 1982
Externally publishedYes

Keywords

  • Bombesin
  • Cysteamine
  • Duodenal ulcers
  • Gastric acid secretion
  • Neuropeptides
  • Neurotensin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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