The effect of intracardiac acetylcholine infusion upon right heart dynamics in patients with rheumatic heart disease studied at rest

Philip Samet; William H. Bernstein; Luciano Fernandez; William De Victoria

doi:10.1016/0002-9149(62)90095-4

The effect of intracardiac acetylcholine infusion upon right heart dynamics in patients with rheumatic heart disease studied at rest

Philip Samet, William H. Bernstein, Luciano Fernandez, William De Victoria

Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Acetylcholine was infused into the right atrium or right ventricle in the course of seventy-nine cardiac catheterizations in sixty-seven patients with rheumatic heart disease with mitral stenosis and/or aortic valve disease. Measurements of pulmonary and systemic arterial pressures and cardiac output were carried out before and during acetylcholine infusion. The data demonstrate a slight pulmonary vasodilator effect of acetylcholine; the magnitude of these changes suggests that acetylcholine offers little promise in the treatment of pulmonary hypertension in patients with mitral stenosis.

Original language	English (US)
Pages (from-to)	32-42
Number of pages	11
Journal	The American Journal of Cardiology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/0002-9149(62)90095-4
State	Published - Jan 1962

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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title = "The effect of intracardiac acetylcholine infusion upon right heart dynamics in patients with rheumatic heart disease studied at rest",

abstract = "Acetylcholine was infused into the right atrium or right ventricle in the course of seventy-nine cardiac catheterizations in sixty-seven patients with rheumatic heart disease with mitral stenosis and/or aortic valve disease. Measurements of pulmonary and systemic arterial pressures and cardiac output were carried out before and during acetylcholine infusion. The data demonstrate a slight pulmonary vasodilator effect of acetylcholine; the magnitude of these changes suggests that acetylcholine offers little promise in the treatment of pulmonary hypertension in patients with mitral stenosis.",

author = "Philip Samet and Bernstein, {William H.} and Luciano Fernandez and Victoria, {William De}",

note = "Funding Information: * From the Cardio-Pulmonary Laboratory and the Department of Medicine, Mt. Sinai Hospital, and the Section of Cardiology, Department of Medicine, University of Miami School of Medicine, Florida. This project was supported in part by a grant from the National Heart Institute, H-4249.",

year = "1962",

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N1 - Funding Information: * From the Cardio-Pulmonary Laboratory and the Department of Medicine, Mt. Sinai Hospital, and the Section of Cardiology, Department of Medicine, University of Miami School of Medicine, Florida. This project was supported in part by a grant from the National Heart Institute, H-4249.

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