Acetylcholine was infused into the right atrium or right ventricle in the course of seventy-nine cardiac catheterizations in sixty-seven patients with rheumatic heart disease with mitral stenosis and/or aortic valve disease. Measurements of pulmonary and systemic arterial pressures and cardiac output were carried out before and during acetylcholine infusion. The data demonstrate a slight pulmonary vasodilator effect of acetylcholine; the magnitude of these changes suggests that acetylcholine offers little promise in the treatment of pulmonary hypertension in patients with mitral stenosis.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine