The effect of intracardiac acetylcholine infusion upon right heart dynamics in patients with rheumatic heart disease studied at rest

Philip Samet, William H. Bernstein, Luciano Fernandez, William De Victoria

Research output: Contribution to journalArticle

Abstract

Acetylcholine was infused into the right atrium or right ventricle in the course of seventy-nine cardiac catheterizations in sixty-seven patients with rheumatic heart disease with mitral stenosis and/or aortic valve disease. Measurements of pulmonary and systemic arterial pressures and cardiac output were carried out before and during acetylcholine infusion. The data demonstrate a slight pulmonary vasodilator effect of acetylcholine; the magnitude of these changes suggests that acetylcholine offers little promise in the treatment of pulmonary hypertension in patients with mitral stenosis.

Original languageEnglish (US)
Pages (from-to)32-42
Number of pages11
JournalThe American Journal of Cardiology
Volume9
Issue number1
DOIs
StatePublished - Jan 1962

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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