The effect of intracardiac acetylcholine infusion upon right heart dynamics in patients with rheumatic heart disease studied at rest

Philip Samet, William H. Bernstein, Luciano Fernandez, William De Victoria

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Acetylcholine was infused into the right atrium or right ventricle in the course of seventy-nine cardiac catheterizations in sixty-seven patients with rheumatic heart disease with mitral stenosis and/or aortic valve disease. Measurements of pulmonary and systemic arterial pressures and cardiac output were carried out before and during acetylcholine infusion. The data demonstrate a slight pulmonary vasodilator effect of acetylcholine; the magnitude of these changes suggests that acetylcholine offers little promise in the treatment of pulmonary hypertension in patients with mitral stenosis.

Original languageEnglish
Pages (from-to)32-42
Number of pages11
JournalThe American journal of cardiology
Issue number1
StatePublished - Jan 1 1962
Externally publishedYes


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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