TY - JOUR
T1 - The effect of intracardiac acetylcholine infusion upon right heart dynamics in patients with rheumatic heart disease studied at rest
AU - Samet, Philip
AU - Bernstein, William H.
AU - Fernandez, Luciano
AU - Victoria, William De
N1 - Funding Information:
* From the Cardio-Pulmonary Laboratory and the Department of Medicine, Mt. Sinai Hospital, and the Section of Cardiology, Department of Medicine, University of Miami School of Medicine, Florida. This project was supported in part by a grant from the National Heart Institute, H-4249.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1962/1
Y1 - 1962/1
N2 - Acetylcholine was infused into the right atrium or right ventricle in the course of seventy-nine cardiac catheterizations in sixty-seven patients with rheumatic heart disease with mitral stenosis and/or aortic valve disease. Measurements of pulmonary and systemic arterial pressures and cardiac output were carried out before and during acetylcholine infusion. The data demonstrate a slight pulmonary vasodilator effect of acetylcholine; the magnitude of these changes suggests that acetylcholine offers little promise in the treatment of pulmonary hypertension in patients with mitral stenosis.
AB - Acetylcholine was infused into the right atrium or right ventricle in the course of seventy-nine cardiac catheterizations in sixty-seven patients with rheumatic heart disease with mitral stenosis and/or aortic valve disease. Measurements of pulmonary and systemic arterial pressures and cardiac output were carried out before and during acetylcholine infusion. The data demonstrate a slight pulmonary vasodilator effect of acetylcholine; the magnitude of these changes suggests that acetylcholine offers little promise in the treatment of pulmonary hypertension in patients with mitral stenosis.
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U2 - 10.1016/0002-9149(62)90095-4
DO - 10.1016/0002-9149(62)90095-4
M3 - Article
C2 - 14496597
AN - SCOPUS:50549176449
VL - 9
SP - 32
EP - 42
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 1
ER -