The effect of intracardiac acetylcholine infusion upon right heart dynamics in patients with rheumatic heart disease studied at rest

Philip Samet, William H. Bernstein, Luciano Fernandez, William De Victoria

Research output: Contribution to journalArticle

Abstract

Acetylcholine was infused into the right atrium or right ventricle in the course of seventy-nine cardiac catheterizations in sixty-seven patients with rheumatic heart disease with mitral stenosis and/or aortic valve disease. Measurements of pulmonary and systemic arterial pressures and cardiac output were carried out before and during acetylcholine infusion. The data demonstrate a slight pulmonary vasodilator effect of acetylcholine; the magnitude of these changes suggests that acetylcholine offers little promise in the treatment of pulmonary hypertension in patients with mitral stenosis.

Original languageEnglish
Pages (from-to)32-42
Number of pages11
JournalThe American journal of cardiology
Volume9
Issue number1
StatePublished - Jan 1 1962
Externally publishedYes

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Rheumatic Heart Disease
Acetylcholine
Mitral Valve Stenosis
Lung
Aortic Diseases
Cardiac Catheterization
Heart Atria
Vasodilator Agents
Aortic Valve
Mitral Valve
Pulmonary Hypertension
Cardiac Output
Heart Ventricles
Arterial Pressure
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The effect of intracardiac acetylcholine infusion upon right heart dynamics in patients with rheumatic heart disease studied at rest. / Samet, Philip; Bernstein, William H.; Fernandez, Luciano; Victoria, William De.

In: The American journal of cardiology, Vol. 9, No. 1, 01.01.1962, p. 32-42.

Research output: Contribution to journalArticle

Samet, Philip ; Bernstein, William H. ; Fernandez, Luciano ; Victoria, William De. / The effect of intracardiac acetylcholine infusion upon right heart dynamics in patients with rheumatic heart disease studied at rest. In: The American journal of cardiology. 1962 ; Vol. 9, No. 1. pp. 32-42.
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