The effect of insulin growth factor-1 on calvarial sutures in a Sprague-Dawley rat.

Seth Thaller, J. Hoyt, H. Tesluk, R. Holmes

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Early investigations attempting to determine the exact pathogenesis of premature closure of the cranial sutures were limited by the untoward sequelae caused by surgical procedures in animal models to simulate the development of craniosynostosis. In an attempt to create a model for evaluating the effects of manipulating the craniofacial sutures without the limitations of associated scarring, we conceived an animal prototype dependent on the effects of insulin growth factor-1 on the anterior frontal suture in a Sprague-Dawley rat model. The experimental group received 2 mg of IGF-1 over a 14-day period via a subcutaneously placed osmotic infusion pump, whereas the age-matched control group received no treatment. We present our preliminary histological results describing the effect of IGF-1 on calvarial sutures.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalThe Journal of craniofacial surgery
Volume4
Issue number1
StatePublished - Jan 1 1993
Externally publishedYes

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Sutures
Sprague Dawley Rats
Intercellular Signaling Peptides and Proteins
Insulin
Insulin-Like Growth Factor I
Cranial Sutures
Infusion Pumps
Craniosynostoses
Cicatrix
Research Design
Animal Models
Control Groups

ASJC Scopus subject areas

  • Surgery

Cite this

The effect of insulin growth factor-1 on calvarial sutures in a Sprague-Dawley rat. / Thaller, Seth; Hoyt, J.; Tesluk, H.; Holmes, R.

In: The Journal of craniofacial surgery, Vol. 4, No. 1, 01.01.1993, p. 35-39.

Research output: Contribution to journalArticle

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