The effect of insulin growth factor-1 on calvarial sutures in a sprague-dawley rat

Seth R. Thaller, James Hoyt, Henry Tesluk, Ralph Holmes

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Early investigations attempting to determine the exact pathogenesis of premature closure of the cranial sutures were limited by the untoward sequelae caused by surgical procedures in animal models to simulate the development of craniosynostosis. In an attempt to create a model for evaluating the effects of manipulating the craniofacial sutures without the limitations of associated scarring, we conceived an animal prototype dependent on the effects of insulin growth factor-1 on the anterior frontal suture in a Sprague-Dawley rat model. The experimental group received 2 mg of IGF-1 over a 14-day period via a subcutaneously placed osmotic infusion pump, whereas the age-matched control group received no treatment. We present our preliminary histological results describing the effect of IGF-1 on calvarial sutures.

Original languageEnglish (US)
Pages (from-to)35-39
Number of pages5
JournalJournal of Craniofacial Surgery
Issue number1
StatePublished - Jan 1993
Externally publishedYes


  • Craniosynostosis
  • Insulin growth factor-1

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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