The effect of hypothalamic deafferentation on somatostatin-like activity in the rat brain

M. J. Brownstein, A. Arimura, R. Fernandez-Durango, A. V. Schally, M. Palkovits, J. S. Kizer

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Abstract

Somatostatin-like activity (SLA) was determined by radioimmunoassay in several brain regions of animals which had either undergone complete deafferentation of the medial basal hypothalamus or a sham-operation. Surgical isolation of the medial basal hypothalamus caused this region to lose most of its SLA, but did not affect activity elsewhere. Similarly, partial (frontal) deafferentation of the medial basal hypothalamus resulted in a substantial decrease in SLA there.

Original languageEnglish (US)
Pages (from-to)246-249
Number of pages4
JournalEndocrinology
Volume100
Issue number1
DOIs
StatePublished - Jan 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology

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    Brownstein, M. J., Arimura, A., Fernandez-Durango, R., Schally, A. V., Palkovits, M., & Kizer, J. S. (1977). The effect of hypothalamic deafferentation on somatostatin-like activity in the rat brain. Endocrinology, 100(1), 246-249. https://doi.org/10.1210/endo-100-1-246