The effect of high K+ depolarization and verapamil on 45Ca2+ fluxes in the canine myocardium

N. J. Lodge, A. L. Bassett, H. Gelband

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effects of high K+ depolarization and verapamil on Ca2+ uptake and the total intracellular Ca2+ content of canine ventricular muscle strips (~0.5 mm thick) were investigated. High K+ (96 mM) increased Ca2+ uptake above control and maintained this enhanced uptake throughout a 90 sec measuring period. Verapamil (5 x 10-6 M) significantly (p < 0.05) inhibited this high K+ stimulated uptake. However, verapamil (5 x 10-6 M) also had a direct effect on Ca2+ fluxes, causing a significant increase in both Ca2+ uptake (p < 0.001) and total intracellular Ca2+ content (p < 0.001) in the resting tissue. Therefore, verapamil's apparent inhibition of high K+ stimulated Ca2+ uptake may have resulted from some mechanism other than Ca2+ channel blockade.

Original languageEnglish
Pages (from-to)222-224
Number of pages3
JournalPflugers Archiv European Journal of Physiology
Volume403
Issue number2
StatePublished - Jan 1 1985
Externally publishedYes

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Depolarization
Verapamil
Canidae
Myocardium
Fluxes
Muscle
Tissue
Muscles

ASJC Scopus subject areas

  • Physiology

Cite this

The effect of high K+ depolarization and verapamil on 45Ca2+ fluxes in the canine myocardium. / Lodge, N. J.; Bassett, A. L.; Gelband, H.

In: Pflugers Archiv European Journal of Physiology, Vol. 403, No. 2, 01.01.1985, p. 222-224.

Research output: Contribution to journalArticle

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