The effect of glycosaminoglycan polysulfuric acid ester on articular cartilage in experimental arthritis: Effects of collagenolytic enzyme activity and cartilage swelling properties

R. D. Altman, D. S. Howell, O. E. Muniz, D. D. Dean

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Some of the effects of the semi-synthetic glycosaminoglycan polysulfuric acid ester (GAGPE) were investigated on the osteoarthritis-like lesions in the Pond-Nuki dog model, in respect to histological grade of anatomical lesions, collagenolytic enzyme activity, and a parameter of collagen network integrity. Prophylactic treatment by intra-articular injections twice weekly for 4 weeks caused amelioration of canine cartilage erosions. Preliminary evidence for suppression of collagenolytic enzyme activity, as well as protection of a tight collagen network studied in the canine cartilage was obtained.

Original languageEnglish (US)
Pages (from-to)127-129
Number of pages3
JournalJournal of Rheumatology
Volume14
Issue numberSPEC. NO.
StatePublished - Dec 1 1987

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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