Some of the effects of the semi-synthetic glycosaminoglycan polysulfuric acid ester (GAGPE) were investigated on the osteoarthritis-like lesions in the Pond-Nuki dog model, in respect to histological grade of anatomical lesions, collagenolytic enzyme activity, and a parameter of collagen network integrity. Prophylactic treatment by intra-articular injections twice weekly for 4 weeks caused amelioration of canine cartilage erosions. Preliminary evidence for suppression of collagenolytic enzyme activity, as well as protection of a tight collagen network studied in the canine cartilage was obtained.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Rheumatology|
|Issue number||SPEC. NO.|
|State||Published - Dec 1 1987|
ASJC Scopus subject areas
- Immunology and Allergy